The Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men

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dc.contributor.authorY Jang-
dc.contributor.authorO Y Kim-
dc.contributor.authorS J Koh-
dc.contributor.authorJ S Chae-
dc.contributor.authorY G Ko-
dc.contributor.authorJ Y Kim-
dc.contributor.authorH Cho-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorJ M Ordovas-
dc.contributor.authorJ H Lee-
dc.date.accessioned2017-04-19T09:05:04Z-
dc.date.available2017-04-19T09:05:04Z-
dc.date.issued2006-
dc.identifier.issn0021-972X-
dc.identifier.uri10.1210/jc.2006-0116ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7567-
dc.description.abstractContext and Objective: It is unclear whether lipoprotein-associated phospholipase A2 (Lp-PLA2) exerts a pro- or antiatherogenic effect on cardiovascular disease (CVD). We investigated the association between Lp-PLA2 variant (V279F and A379V) and CVD in Korean men. Design: CVD patients (n = 532) and healthy controls (n = 670) were genotyped for the Lp-PLA2 polymorphism (V279F and A379V). Main Outcome Measures: We calculated odds ratio (OR) on CVD risk and measured anthropometries, lipid profiles, low-density lipoprotein (LDL) particle size, oxidized LDL, lipid peroxides, and Lp-PLA2 activity. Results: The presence of the 279F allele was associated with a lower risk of CVD [OR 0.646 (95% confidence interval 0.490-0.850), P = 0.002], and the association still remained after adjustments for age, body mass index, waist circumference, waist to hip ratio, cigarette smoking, and alcohol consumption [OR 0.683 (95% confidence interval 0.512-0.911), P = 0.009]. Lp-PLA2 activity was lower in CVD patients taking a lipid-lowering drug (31%), those not taking a lipid-lowering drug (26%), and control subjects (23%) with the V/F genotype, compared with those with the V/V genotype. Subjects with the F/F genotype in controls and two CVD patients groups showed no appreciable enzymatic activity. Control subjects with the V/F genotype had larger LDL particle size than those with the V/V genotype. In addition, control subjects carrying the F allele showed lower malondialdehyde concentrations. On the other hand, we found no significant relationship between A379V genotype and CVD risk. Conclusions: The association of the F279 loss of function variant with the reduced risk of CVD supports the concept that Lp-PLA2 plays a proatherogenic and causative role in CVD.-
dc.publisherEndocrine Soc-
dc.titleThe Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men-
dc.title.alternativeThe Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men-
dc.typeArticle-
dc.citation.titleJournal of Clinical Endocrinology & Metabolism-
dc.citation.number9-
dc.citation.endPage3527-
dc.citation.startPage3521-
dc.citation.volume91-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName장양수-
dc.contributor.alternativeName김오연-
dc.contributor.alternativeName고수정-
dc.contributor.alternativeName채제숙-
dc.contributor.alternativeName고영국-
dc.contributor.alternativeName김지영-
dc.contributor.alternativeName조흥근-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeNameOrdovas-
dc.contributor.alternativeName이종호-
dc.identifier.bibliographicCitationJournal of Clinical Endocrinology & Metabolism, vol. 91, no. 9, pp. 3521-3527-
dc.identifier.doi10.1210/jc.2006-0116-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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