Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis

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Title
Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis
Author(s)
In-Kyoung Lee; Jin-Young Jung; S J Seok; W G Kim; Bong Sik Yun
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 21, pp. 5621-5624
Publication Year
2006
Abstract
New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their structures were established by various spectroscopic analyses. Compounds 1 and 3 were proposed to be biosynthesized from the oxidative coupling of the precursor hispidin with 3,4-dihydroxybenzaldehyde and 3,4-dihydroxybenzoic acid, respectively. These compounds exhibited significant scavenging activity against the ABTS radical cation, and compounds 2 and 4 displayed moderate superoxide radical scavenging activity.
Keyword
BiogenesisFree radical scavengerHispidin derivativeInonotus xeranticusMushroom
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2006.08.016
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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