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- Title
- Potent inhibition of the inductions of inducible nitric oxide synthase and cyclooxygenase-2 by taiwaniaflavone
- Author(s)
- Y R Pokharel; J W Yang; J Y Kim; Hyun Woo Oh; H G Jeong; E R Woo; K W Kang
- Bibliographic Citation
- Nitric Oxide-Biology and Chemistry, vol. 15, no. 3, pp. 217-225
- Publication Year
- 2006
- Abstract
- The improper productions of nitric oxide and prostaglandins following the inductions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are involved in the pathogenesis of chronic inflammation. Selaginella tamariscina is used as an oriental medicine for its anti-inflammatory effects. Here, we isolated taiwaniaflavone from S. tamariscina and investigated whether taiwaniaflavone affects the induction of iNOS and COX-2 in RAW264.7 macrophages stimulated with lipopolysaccharide. We found that taiwaniaflavone blocks the transactivations of iNOS and COX-2 genes by blocking the nuclear translocation of p65 and subsequent nuclear factor-κB inactivation. It is known that NF-κB activation is controlled by the phosphorylation and subsequent degradation of I-κBα, and in the present study, we found that the phosphorylation and degradation of I-κBα were also inhibited by taiwaniaflavone. Our findings indicate that taiwaniaflavone may provide a developmental basis for an agent against inflammatory diseases.
- Keyword
- COX-2iNOSNF-κBSelaginella tamariscinaTaiwaniaflavone
- ISSN
- 1089-8603
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.niox.2006.01.001
- Type
- Article
- Appears in Collections:
- Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
- Files in This Item:
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