Potent inhibition of the inductions of inducible nitric oxide synthase and cyclooxygenase-2 by taiwaniaflavone

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Title
Potent inhibition of the inductions of inducible nitric oxide synthase and cyclooxygenase-2 by taiwaniaflavone
Author(s)
Y R Pokharel; J W Yang; J Y Kim; Hyun Woo Oh; H G Jeong; E R Woo; K W Kang
Bibliographic Citation
Nitric Oxide-Biology and Chemistry, vol. 15, no. 3, pp. 217-225
Publication Year
2006
Abstract
The improper productions of nitric oxide and prostaglandins following the inductions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are involved in the pathogenesis of chronic inflammation. Selaginella tamariscina is used as an oriental medicine for its anti-inflammatory effects. Here, we isolated taiwaniaflavone from S. tamariscina and investigated whether taiwaniaflavone affects the induction of iNOS and COX-2 in RAW264.7 macrophages stimulated with lipopolysaccharide. We found that taiwaniaflavone blocks the transactivations of iNOS and COX-2 genes by blocking the nuclear translocation of p65 and subsequent nuclear factor-κB inactivation. It is known that NF-κB activation is controlled by the phosphorylation and subsequent degradation of I-κBα, and in the present study, we found that the phosphorylation and degradation of I-κBα were also inhibited by taiwaniaflavone. Our findings indicate that taiwaniaflavone may provide a developmental basis for an agent against inflammatory diseases.
Keyword
COX-2iNOSNF-κBSelaginella tamariscinaTaiwaniaflavone
ISSN
1089-8603
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.niox.2006.01.001
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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