Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Seung-Wook Chi | - |
| dc.contributor.author | Do-heyoung Kim | - |
| dc.contributor.author | B M Olivera | - |
| dc.contributor.author | J M McIntosh | - |
| dc.contributor.author | Kyou Hoon Han | - |
| dc.date.accessioned | 2017-04-19T09:05:17Z | - |
| dc.date.available | 2017-04-19T09:05:17Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.issn | 0006-291X | - |
| dc.identifier.uri | 10.1016/j.bbrc.2006.04.099 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7586 | - |
| dc.description.abstract | α-Conotoxin OmIA from Conus omaria is the only α-conotoxin that shows a ∼20-fold higher affinity to the α3β2 over the α6β2 subtype of nicotinic acetylcholine receptor. We have determined a three-dimensional structure of α-conotoxin OmIA by nuclear magnetic resonance spectroscopy. α-Conotoxin OmIA has an "ω-shaped" overall topology with His5-Asn12 forming an α-helix. Structural features of α-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related α4/7 subfamily conotoxins. Reduced size of the hydrophilic area in α-conotoxin OmIA seems to be associated with the reduced affinity towards the α6β2 nAChR subtype. | - |
| dc.publisher | Elsevier | - |
| dc.title | Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes | - |
| dc.title.alternative | Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes | - |
| dc.type | Article | - |
| dc.citation.title | Biochemical and Biophysical Research Communications | - |
| dc.citation.number | 1 | - |
| dc.citation.endPage | 254 | - |
| dc.citation.startPage | 248 | - |
| dc.citation.volume | 345 | - |
| dc.contributor.affiliatedAuthor | Seung-Wook Chi | - |
| dc.contributor.affiliatedAuthor | Do-heyoung Kim | - |
| dc.contributor.affiliatedAuthor | Kyou Hoon Han | - |
| dc.contributor.alternativeName | 지승욱 | - |
| dc.contributor.alternativeName | 김도형 | - |
| dc.contributor.alternativeName | Olivera | - |
| dc.contributor.alternativeName | McIntosh | - |
| dc.contributor.alternativeName | 한규훈 | - |
| dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 345, no. 1, pp. 248-254 | - |
| dc.identifier.doi | 10.1016/j.bbrc.2006.04.099 | - |
| dc.subject.keyword | α-Conotoxin | - |
| dc.subject.keyword | nicotinic acetylcholine receptor | - |
| dc.subject.keyword | NMR | - |
| dc.subject.keyword | peptide | - |
| dc.subject.keyword | solution structure | - |
| dc.subject.local | α-conotoxin | - |
| dc.subject.local | α-Conotoxin | - |
| dc.subject.local | nicotinic acetylcholine receptor (nAChR) | - |
| dc.subject.local | Nicotinic acetylcholine receptors (nAChRs) | - |
| dc.subject.local | Nicotinic acetylcholine receptor | - |
| dc.subject.local | nicotinic acetylcholine receptor | - |
| dc.subject.local | NMR | - |
| dc.subject.local | nuclear magnetic resonance (Nmr) | - |
| dc.subject.local | Nuclear magnetic resonance | - |
| dc.subject.local | nuclear magnetic resonance | - |
| dc.subject.local | Nuclear magnetic resonance (NMR) | - |
| dc.subject.local | peptide | - |
| dc.subject.local | Peptides | - |
| dc.subject.local | Peptide | - |
| dc.subject.local | Solution structure | - |
| dc.subject.local | solution structure | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Division of A.I. & Biomedical Research > 1. Journal Articles
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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