Expression of the RERG gene is gender-dependent in hepatocellular carcinoma and regulated by histone deacetyltransferases

Cited 9 time in scopus
Metadata Downloads
Title
Expression of the RERG gene is gender-dependent in hepatocellular carcinoma and regulated by histone deacetyltransferases
Author(s)
A G Wang; W Fang; Y H Han; Sang-Mi Cho; J Y Choi; K H Lee; W H Kim; J M Kim; M G Park; Dae Yeul Yu; Nam-Soon Kim; D S Lee
Bibliographic Citation
Journal of Korean Medical Science, vol. 21, no. 5, pp. 891-896
Publication Year
2006
Abstract
Ras-related, estrogen-regulated, and growth-inhibitory gene (RERG) is a novel gene that was first reported in breast cancer. However, the functions of RERG are largely unknown in other tumor types. In this study, RERG expression was analyzed in hepatocellular carcinomas of human patients using reverse transcriptase PCR analysis. In addition, the possible regulation of RERG expression by histone deacetyltransferases (HDACs) was studied in several cell lines. Interestingly, the expression of RERG gene was increased in hepatocellular carcinoma (HCC) of male patients (57.9%) but decreased in HCC of females (87.5%) comparison with paired peri-tumoral tissues. Moreover, RERG gene expression was increased in murine hepatoma Hepa1-6 cells, human breast tumor MDA-MB-231 cells, and mouse normal fibroblast NIH3T3 cells after treated by HDAC inhibitor, trichostatin A. Our results suggest that RERG may function in a gender-dependent manner in hepatic tumorigenesis and that the expression of this gene may be regulated by an HDAC-related signaling pathway.
Keyword
Carcinoma, hepatocellularHistone acetyltransferasesRas-related estrogen-regulated and growth-inhibitory gene (RERG)Sex
ISSN
1011-8934
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3346/jkms.2006.21.5.891
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.