Hormonal activity of AIMP1/p43 for glucose homeostasis

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dc.contributor.authorS G Park-
dc.contributor.authorY S Kang-
dc.contributor.authorJ Y Kim-
dc.contributor.authorC S Lee-
dc.contributor.authorY G Ko-
dc.contributor.authorW J Lee-
dc.contributor.authorK U Lee-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorS Kim-
dc.date.accessioned2017-04-19T09:05:22Z-
dc.date.available2017-04-19T09:05:22Z-
dc.date.issued2006-
dc.identifier.issn00278424-
dc.identifier.uri10.1073/pnas.0602045103ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7616-
dc.description.abstractAIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.-
dc.publisherNatl Acad Sciences-
dc.titleHormonal activity of AIMP1/p43 for glucose homeostasis-
dc.title.alternativeHormonal activity of AIMP1/p43 for glucose homeostasis-
dc.typeArticle-
dc.citation.titleProceedings of National Academy of Sciences of United States of America-
dc.citation.number40-
dc.citation.endPage14918-
dc.citation.startPage14913-
dc.citation.volume103-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.alternativeName박상규-
dc.contributor.alternativeName강영선-
dc.contributor.alternativeName김진영-
dc.contributor.alternativeName이창석-
dc.contributor.alternativeName고영규-
dc.contributor.alternativeName이우제-
dc.contributor.alternativeName이기업-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName김성훈-
dc.identifier.bibliographicCitationProceedings of National Academy of Sciences of United States of America, vol. 103, no. 40, pp. 14913-14918-
dc.identifier.doi10.1073/pnas.0602045103-
dc.subject.keywordaminoacyl-tRNA synthetase-
dc.subject.keywordglucagon-
dc.subject.keywordpancreas-
dc.subject.localaminoacyl-tRNA synthetase-
dc.subject.localAminoacyl-tRNA synthetase-
dc.subject.localglucagon-
dc.subject.localpancreas-
dc.subject.localPancreas-
dc.description.journalClassY-
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Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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