DC Field | Value | Language |
---|---|---|
dc.contributor.author | J C Heo | - |
dc.contributor.author | J Y Park | - |
dc.contributor.author | S U Woo | - |
dc.contributor.author | J R Rho | - |
dc.contributor.author | Ho Jae Lee | - |
dc.contributor.author | Sung Uk Kim | - |
dc.contributor.author | Yung Hee Kho | - |
dc.contributor.author | S H Lee | - |
dc.date.accessioned | 2017-04-19T09:05:27Z | - |
dc.date.available | 2017-04-19T09:05:27Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | 10.1248/bpb.29.2256 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7640 | - |
dc.description.abstract | Dykellic acid, a novel factor initially identified from the culture broth of Westerdykella multispora F50733, has been shown to inhibit matrix metalloprotease 9 activity, caspase-3 activity, B cell proliferation and LPS-induced IgM production, suggesting that this factor may have anti-cancer effects. In an effort to further address the possible anti-tumoral effects of dykellic acid, we used wound healing, invasion and RhoA-GTP assays to examine the effects of dykellic acid on cell migration, invasion and angiogenesis. Our results revealed that dykellic acid dose-dependently inhibits B16 cell migration and motility, and inhibits HUVEC tube formation. Western blot analysis of the active form of RhoA (RhoA-GTP) showed that dykellic acid treatment decreased the levels of RhoA-GTP. These findings collectively suggest that dykellic acid may have both anti-metastatic and antiangiogenic acitivites, and provides the first evidence for the involvement of RhoA in dykellic acid-induced effects. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression = 다이켈릭산이 RhoA-GTP 발현에 의해 세포이동과 tube 형성을 저해 | - |
dc.title.alternative | Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 11 | - |
dc.citation.endPage | 2259 | - |
dc.citation.startPage | 2256 | - |
dc.citation.volume | 29 | - |
dc.contributor.affiliatedAuthor | Ho Jae Lee | - |
dc.contributor.affiliatedAuthor | Sung Uk Kim | - |
dc.contributor.affiliatedAuthor | Yung Hee Kho | - |
dc.contributor.alternativeName | 허진철 | - |
dc.contributor.alternativeName | 박자영 | - |
dc.contributor.alternativeName | 우상욱 | - |
dc.contributor.alternativeName | 노재랑 | - |
dc.contributor.alternativeName | 이호재 | - |
dc.contributor.alternativeName | 김성욱 | - |
dc.contributor.alternativeName | 고영희 | - |
dc.contributor.alternativeName | 이상한 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 29, no. 11, pp. 2256-2259 | - |
dc.identifier.doi | 10.1248/bpb.29.2256 | - |
dc.subject.keyword | Angiogenesis | - |
dc.subject.keyword | Cell migration | - |
dc.subject.keyword | Dykellic acid | - |
dc.subject.keyword | Invasion | - |
dc.subject.keyword | RhoA | - |
dc.subject.keyword | RhoA-GTP | - |
dc.subject.local | Angiogenesis | - |
dc.subject.local | angiogenesis | - |
dc.subject.local | cell migration | - |
dc.subject.local | Cell migration | - |
dc.subject.local | Dykellic acid | - |
dc.subject.local | dykellic acid | - |
dc.subject.local | invasion | - |
dc.subject.local | Invasion | - |
dc.subject.local | RHOA | - |
dc.subject.local | RhoA | - |
dc.subject.local | RhoA-GTP | - |
dc.description.journalClass | Y | - |
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