Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression = 다이켈릭산이 RhoA-GTP 발현에 의해 세포이동과 tube 형성을 저해

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dc.contributor.authorJ C Heo-
dc.contributor.authorJ Y Park-
dc.contributor.authorS U Woo-
dc.contributor.authorJ R Rho-
dc.contributor.authorHo Jae Lee-
dc.contributor.authorSung Uk Kim-
dc.contributor.authorYung Hee Kho-
dc.contributor.authorS H Lee-
dc.date.accessioned2017-04-19T09:05:27Z-
dc.date.available2017-04-19T09:05:27Z-
dc.date.issued2006-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.29.2256ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7640-
dc.description.abstractDykellic acid, a novel factor initially identified from the culture broth of Westerdykella multispora F50733, has been shown to inhibit matrix metalloprotease 9 activity, caspase-3 activity, B cell proliferation and LPS-induced IgM production, suggesting that this factor may have anti-cancer effects. In an effort to further address the possible anti-tumoral effects of dykellic acid, we used wound healing, invasion and RhoA-GTP assays to examine the effects of dykellic acid on cell migration, invasion and angiogenesis. Our results revealed that dykellic acid dose-dependently inhibits B16 cell migration and motility, and inhibits HUVEC tube formation. Western blot analysis of the active form of RhoA (RhoA-GTP) showed that dykellic acid treatment decreased the levels of RhoA-GTP. These findings collectively suggest that dykellic acid may have both anti-metastatic and antiangiogenic acitivites, and provides the first evidence for the involvement of RhoA in dykellic acid-induced effects.-
dc.publisherPharmaceutical Soc Japan-
dc.titleDykellic acid inhibits cell migration and tube formation by RhoA-GTP expression = 다이켈릭산이 RhoA-GTP 발현에 의해 세포이동과 tube 형성을 저해-
dc.title.alternativeDykellic acid inhibits cell migration and tube formation by RhoA-GTP expression-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number11-
dc.citation.endPage2259-
dc.citation.startPage2256-
dc.citation.volume29-
dc.contributor.affiliatedAuthorHo Jae Lee-
dc.contributor.affiliatedAuthorSung Uk Kim-
dc.contributor.affiliatedAuthorYung Hee Kho-
dc.contributor.alternativeName허진철-
dc.contributor.alternativeName박자영-
dc.contributor.alternativeName우상욱-
dc.contributor.alternativeName노재랑-
dc.contributor.alternativeName이호재-
dc.contributor.alternativeName김성욱-
dc.contributor.alternativeName고영희-
dc.contributor.alternativeName이상한-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 29, no. 11, pp. 2256-2259-
dc.identifier.doi10.1248/bpb.29.2256-
dc.subject.keywordAngiogenesis-
dc.subject.keywordCell migration-
dc.subject.keywordDykellic acid-
dc.subject.keywordInvasion-
dc.subject.keywordRhoA-
dc.subject.keywordRhoA-GTP-
dc.subject.localAngiogenesis-
dc.subject.localangiogenesis-
dc.subject.localcell migration-
dc.subject.localCell migration-
dc.subject.localDykellic acid-
dc.subject.localdykellic acid-
dc.subject.localinvasion-
dc.subject.localInvasion-
dc.subject.localRHOA-
dc.subject.localRhoA-
dc.subject.localRhoA-GTP-
dc.description.journalClassY-
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