DC Field | Value | Language |
---|---|---|
dc.contributor.author | J H Won | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | K J Yun | - |
dc.contributor.author | J H Lee | - |
dc.contributor.author | N I Back | - |
dc.contributor.author | H G Chung | - |
dc.contributor.author | S A Chung | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | M S Choi | - |
dc.contributor.author | K T Lee | - |
dc.date.accessioned | 2017-04-19T09:05:28Z | - |
dc.date.available | 2017-04-19T09:05:28Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | 10.1055/s-2006-947201 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7642 | - |
dc.description.abstract | During our efforts to find bioactive natural products with anti-inflammatory activity, we isolated gigantol from the whole plants of Cymbidium goeringii (Orchidaceae) by activity-guided Chromatographic fractionation. Gigantol was found to have potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Consistent with these findings, gigantol suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein and mRNA levels in RAW 264.7 cells in a concentration-dependent manner. Our data also indicate that gigantol is a potent inhibitor of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) release and influenced the mRNA expression levels of these cytokines in a dose-dependent manner. Furthermore, a reporter gene assay for nuclear factor kappa B (NF-κB) and an electromobility shift assay (EMSA) demonstrated that gigantol effectively inhibited the activation of NF-κB, which is necessary for the expression of iNOS, COX-2, TNF-α, IL-1β and IL-6. Thus, our studies suggest that gigantol inhibits LPS-induced iNOS and COX-2 expression by blocking NF-κB activation. | - |
dc.publisher | Georg Thieme Verlag Kg | - |
dc.title | Gigantol isolated from the whole plants of Cymbidium goeringii inhibits the LPS-induced iNOS and COX-2 expression via NF-κB inactivation in RAW264.7 macrophages cells | - |
dc.title.alternative | Gigantol isolated from the whole plants of Cymbidium goeringii inhibits the LPS-induced iNOS and COX-2 expression via NF-κB inactivation in RAW264.7 macrophages cells | - |
dc.type | Article | - |
dc.citation.title | Planta Medica | - |
dc.citation.number | 13 | - |
dc.citation.endPage | 1187 | - |
dc.citation.startPage | 1181 | - |
dc.citation.volume | 72 | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 원종헌 | - |
dc.contributor.alternativeName | 김지연 | - |
dc.contributor.alternativeName | 윤경진 | - |
dc.contributor.alternativeName | 이진희 | - |
dc.contributor.alternativeName | 백남인 | - |
dc.contributor.alternativeName | 정해곤 | - |
dc.contributor.alternativeName | 정선아 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 최명숙 | - |
dc.contributor.alternativeName | 이경태 | - |
dc.identifier.bibliographicCitation | Planta Medica, vol. 72, no. 13, pp. 1181-1187 | - |
dc.identifier.doi | 10.1055/s-2006-947201 | - |
dc.subject.keyword | Cyclooxygenase-2 | - |
dc.subject.keyword | Cymbidium goeringii | - |
dc.subject.keyword | Gigantol | - |
dc.subject.keyword | Inducible nitric oxide synthase | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Orhidaceae | - |
dc.subject.local | Cyclooxygenase 2 | - |
dc.subject.local | cyclooxygenase-2 | - |
dc.subject.local | Cyclooxygenase-2 | - |
dc.subject.local | Cyclooxygenase-2 (COX-2) | - |
dc.subject.local | cymbidium goeringii | - |
dc.subject.local | Cymbidium goeringii | - |
dc.subject.local | Gigantol | - |
dc.subject.local | Inducible nitric oxide synthase (iNOS) | - |
dc.subject.local | Inducible nitric oxide synthase | - |
dc.subject.local | inducible nnitric oxide synthase | - |
dc.subject.local | iNOS | - |
dc.subject.local | Inducible nitric oxide synthease (iNOS) | - |
dc.subject.local | INOS | - |
dc.subject.local | inducible nitric oxide synthase | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | Orhidaceae | - |
dc.description.journalClass | Y | - |
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