Gigantol isolated from the whole plants of Cymbidium goeringii inhibits the LPS-induced iNOS and COX-2 expression via NF-κB inactivation in RAW264.7 macrophages cells

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dc.contributor.authorJ H Won-
dc.contributor.authorJ Y Kim-
dc.contributor.authorK J Yun-
dc.contributor.authorJ H Lee-
dc.contributor.authorN I Back-
dc.contributor.authorH G Chung-
dc.contributor.authorS A Chung-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorM S Choi-
dc.contributor.authorK T Lee-
dc.date.accessioned2017-04-19T09:05:28Z-
dc.date.available2017-04-19T09:05:28Z-
dc.date.issued2006-
dc.identifier.issn0032-0943-
dc.identifier.uri10.1055/s-2006-947201ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7642-
dc.description.abstractDuring our efforts to find bioactive natural products with anti-inflammatory activity, we isolated gigantol from the whole plants of Cymbidium goeringii (Orchidaceae) by activity-guided Chromatographic fractionation. Gigantol was found to have potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Consistent with these findings, gigantol suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein and mRNA levels in RAW 264.7 cells in a concentration-dependent manner. Our data also indicate that gigantol is a potent inhibitor of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) release and influenced the mRNA expression levels of these cytokines in a dose-dependent manner. Furthermore, a reporter gene assay for nuclear factor kappa B (NF-κB) and an electromobility shift assay (EMSA) demonstrated that gigantol effectively inhibited the activation of NF-κB, which is necessary for the expression of iNOS, COX-2, TNF-α, IL-1β and IL-6. Thus, our studies suggest that gigantol inhibits LPS-induced iNOS and COX-2 expression by blocking NF-κB activation.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleGigantol isolated from the whole plants of Cymbidium goeringii inhibits the LPS-induced iNOS and COX-2 expression via NF-κB inactivation in RAW264.7 macrophages cells-
dc.title.alternativeGigantol isolated from the whole plants of Cymbidium goeringii inhibits the LPS-induced iNOS and COX-2 expression via NF-κB inactivation in RAW264.7 macrophages cells-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number13-
dc.citation.endPage1187-
dc.citation.startPage1181-
dc.citation.volume72-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName원종헌-
dc.contributor.alternativeName김지연-
dc.contributor.alternativeName윤경진-
dc.contributor.alternativeName이진희-
dc.contributor.alternativeName백남인-
dc.contributor.alternativeName정해곤-
dc.contributor.alternativeName정선아-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName최명숙-
dc.contributor.alternativeName이경태-
dc.identifier.bibliographicCitationPlanta Medica, vol. 72, no. 13, pp. 1181-1187-
dc.identifier.doi10.1055/s-2006-947201-
dc.subject.keywordCyclooxygenase-2-
dc.subject.keywordCymbidium goeringii-
dc.subject.keywordGigantol-
dc.subject.keywordInducible nitric oxide synthase-
dc.subject.keywordNF-κB-
dc.subject.keywordOrhidaceae-
dc.subject.localCyclooxygenase 2-
dc.subject.localcyclooxygenase-2-
dc.subject.localCyclooxygenase-2-
dc.subject.localCyclooxygenase-2 (COX-2)-
dc.subject.localcymbidium goeringii-
dc.subject.localCymbidium goeringii-
dc.subject.localGigantol-
dc.subject.localInducible nitric oxide synthase (iNOS)-
dc.subject.localInducible nitric oxide synthase-
dc.subject.localinducible nnitric oxide synthase-
dc.subject.localiNOS-
dc.subject.localInducible nitric oxide synthease (iNOS)-
dc.subject.localINOS-
dc.subject.localinducible nitric oxide synthase-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localOrhidaceae-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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