DC Field | Value | Language |
---|---|---|
dc.contributor.author | S Kang-Park | - |
dc.contributor.author | Ji-Hye Lim | - |
dc.contributor.author | J H Lee | - |
dc.contributor.author | Young Ik Lee | - |
dc.date.accessioned | 2017-04-19T09:05:28Z | - |
dc.date.available | 2017-04-19T09:05:28Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0168-1702 | - |
dc.identifier.uri | 10.1016/j.virusres.2006.06.010 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7646 | - |
dc.description.abstract | PTEN gene, a novel tumor suppressor is frequently mutated or deleted in several malignancies including human hepatocellular carcinoma (HCC). We report previously that human hepatitis B virus-X (HBx) protein achieves protection from apoptotic cell death through-PI3K-Akt-Bad signaling that is p53-independent in liver cells (JBC; 276, 16969 (2000)). In this report, we demonstrated the PTEN effect on HBx induced anti-apoptotic signaling in Chang liver cells (CHL). Expression of PTEN in CHL cells downregulate HBx induced PI3K, Akt activities, Akt, Bad phosphorylations, decreased caspase 3 activity and protection from DNA fragmentations. PTEN suppression of CHL cell growth at G1 phase (JBC;278,4057(2003)) in cell cycle analysis, which is overcome by HBx activated Akt/PKB further confirmed that same PI3K/Akt pathway is involved in cell survival and apoptosis by HBx and PTEN. PTEN suppression of HBx-mediated cell survival through PI3K pathway is specific, since PTEN does not suppress the effect of HBx on the protection from Fas-mediated apoptosis. Taken together, these findings demonstrate that PTEN potently modulate HBx-mediated signaling and is a viable target in therapeutic approaches to inhibit the formation of HCC caused by HBV infections. | - |
dc.publisher | Elsevier | - |
dc.title | PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells | - |
dc.title.alternative | PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells | - |
dc.type | Article | - |
dc.citation.title | Virus Research | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 60 | - |
dc.citation.startPage | 53 | - |
dc.citation.volume | 122 | - |
dc.contributor.affiliatedAuthor | Ji-Hye Lim | - |
dc.contributor.affiliatedAuthor | Young Ik Lee | - |
dc.contributor.alternativeName | 박숙미 | - |
dc.contributor.alternativeName | 임지혜 | - |
dc.contributor.alternativeName | 이제 | - |
dc.contributor.alternativeName | 이영익 | - |
dc.identifier.bibliographicCitation | Virus Research, vol. 122, no. 1, pp. 53-60 | - |
dc.identifier.doi | 10.1016/j.virusres.2006.06.010 | - |
dc.subject.keyword | anti-apoptosis | - |
dc.subject.keyword | hepatitis B | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | protein | - |
dc.subject.keyword | PTEN | - |
dc.subject.keyword | virus-X | - |
dc.subject.local | Anti-apoptosis | - |
dc.subject.local | anti-apoptosis | - |
dc.subject.local | antiapoptosis | - |
dc.subject.local | Hepatitis B | - |
dc.subject.local | hepatitis B | - |
dc.subject.local | Hepatocellular carcinoma | - |
dc.subject.local | Hepatocellular carcinoma (HCC) | - |
dc.subject.local | Hepatocellular carcinomas | - |
dc.subject.local | hepatocellular carcinoma | - |
dc.subject.local | hepatocellular carcinoma (HCC) | - |
dc.subject.local | Protein | - |
dc.subject.local | Proteins | - |
dc.subject.local | PROTEINS | - |
dc.subject.local | protein | - |
dc.subject.local | proteins | - |
dc.subject.local | proetin | - |
dc.subject.local | PTEN | - |
dc.subject.local | virus-X | - |
dc.description.journalClass | Y | - |
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