PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells

Cited 32 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorS Kang-Park-
dc.contributor.authorJi-Hye Lim-
dc.contributor.authorJ H Lee-
dc.contributor.authorYoung Ik Lee-
dc.date.accessioned2017-04-19T09:05:28Z-
dc.date.available2017-04-19T09:05:28Z-
dc.date.issued2006-
dc.identifier.issn0168-1702-
dc.identifier.uri10.1016/j.virusres.2006.06.010ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7646-
dc.description.abstractPTEN gene, a novel tumor suppressor is frequently mutated or deleted in several malignancies including human hepatocellular carcinoma (HCC). We report previously that human hepatitis B virus-X (HBx) protein achieves protection from apoptotic cell death through-PI3K-Akt-Bad signaling that is p53-independent in liver cells (JBC; 276, 16969 (2000)). In this report, we demonstrated the PTEN effect on HBx induced anti-apoptotic signaling in Chang liver cells (CHL). Expression of PTEN in CHL cells downregulate HBx induced PI3K, Akt activities, Akt, Bad phosphorylations, decreased caspase 3 activity and protection from DNA fragmentations. PTEN suppression of CHL cell growth at G1 phase (JBC;278,4057(2003)) in cell cycle analysis, which is overcome by HBx activated Akt/PKB further confirmed that same PI3K/Akt pathway is involved in cell survival and apoptosis by HBx and PTEN. PTEN suppression of HBx-mediated cell survival through PI3K pathway is specific, since PTEN does not suppress the effect of HBx on the protection from Fas-mediated apoptosis. Taken together, these findings demonstrate that PTEN potently modulate HBx-mediated signaling and is a viable target in therapeutic approaches to inhibit the formation of HCC caused by HBV infections.-
dc.publisherElsevier-
dc.titlePTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells-
dc.title.alternativePTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells-
dc.typeArticle-
dc.citation.titleVirus Research-
dc.citation.number1-
dc.citation.endPage60-
dc.citation.startPage53-
dc.citation.volume122-
dc.contributor.affiliatedAuthorJi-Hye Lim-
dc.contributor.affiliatedAuthorYoung Ik Lee-
dc.contributor.alternativeName박숙미-
dc.contributor.alternativeName임지혜-
dc.contributor.alternativeName이제-
dc.contributor.alternativeName이영익-
dc.identifier.bibliographicCitationVirus Research, vol. 122, no. 1, pp. 53-60-
dc.identifier.doi10.1016/j.virusres.2006.06.010-
dc.subject.keywordanti-apoptosis-
dc.subject.keywordhepatitis B-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordprotein-
dc.subject.keywordPTEN-
dc.subject.keywordvirus-X-
dc.subject.localAnti-apoptosis-
dc.subject.localanti-apoptosis-
dc.subject.localantiapoptosis-
dc.subject.localHepatitis B-
dc.subject.localhepatitis B-
dc.subject.localHepatocellular carcinoma-
dc.subject.localHepatocellular carcinoma (HCC)-
dc.subject.localHepatocellular carcinomas-
dc.subject.localhepatocellular carcinoma-
dc.subject.localhepatocellular carcinoma (HCC)-
dc.subject.localProtein-
dc.subject.localProteins-
dc.subject.localPROTEINS-
dc.subject.localprotein-
dc.subject.localproteins-
dc.subject.localproetin-
dc.subject.localPTEN-
dc.subject.localvirus-X-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.