Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341: 1. taxonomy, fermentation, isolation, and biological activities

Cited 20 time in scopus
Metadata Downloads
Title
Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341: 1. taxonomy, fermentation, isolation, and biological activities
Author(s)
T M Yoon; J W Kim; J G Kim; Won Gon Kim; J W Suh
Bibliographic Citation
Journal of Antibiotics, vol. 59, no. 10, pp. 633-639
Publication Year
2006
Abstract
In our screening program for new antifungal agents from microbial secondary metabolites, we isolated two new isoflavonol glycosides, genistein 7-α-L-6-deoxy-talopyranoside (talosin A) and genistein 4′,7-di-α-L-6-deoxy-talopyranoside (talosin B), from the culture broth of Kitasatospora kifunensis MJM341. The talosins exhibited strong antifungal activity against Candida albicans, Aspergillus niger and Cryptococcus neoformans with minimal inhibitory concentrations (MIC) in the range of 3-15 μg/ml while genistein and genistein-7-glucopyranoside did not show antifungal activity at 100 μg/ml. These talosins are the first isoflavonol glycosides with a 6-deoxy-talose sugar component and they may be useful as antifungal agents with low toxicity because of no visible cytotoxicity against the human hepatic HepG2 cell.
Keyword
6-deoxy-taloseantifungal agentgenisteinisoflavonol glycosidekitasatospora kifunensistalosin Atalosin B
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ja.2006.84
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.