Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341: 2. physicochemical properties and structure determination

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Title
Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341: 2. physicochemical properties and structure determination
Author(s)
Won Gon Kim; T M Yoon; H J Kwon; J W Suh
Bibliographic Citation
Journal of Antibiotics, vol. 59, no. 10, pp. 640-645
Publication Year
2006
Abstract
In our screening program for new antifungal agents from microbial secondary metabolites, two new isoflavonol glycosides with potent antifungal activity, talosins A and B, were isolated from the culture broth of Kitasatospora kifunensis MJM341. Talosins A and B were determined to be genistein 7-α-L-6-deoxy-talopyranoside and genistein 4′,7-di-α-L-6- deoxy-talopyranoside, respectively, by spectroscopic studies. They are the first flavonoid glycosides incorporating 6-deoxy-talose as a sugar component.
Keyword
kitasatospora kifunensistalosin Atalosin Bisoflavonol glycoside6-deoxy-taloseantifungal agentgenistein
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ja.2006.85
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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