Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms

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Title
Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms
Author(s)
Y H Choi; E M Shin; Y S Kim; X F Cai; Jung Joon Lee; H P Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 29, no. 4, pp. 293-297
Publication Year
2006
Abstract
The fruits of Evodia rutaecarpa Benth (Rutaceae) has long been used for inflammatory disorders and some anti-inflammatory actions of its constituents such as dehydroevodiamine, evodiamine and rutaecarpine were previously reported. Since the pharmacological data is not sufficient to clearly establish the scientific rationale of anti-inflammatory medicinal use of this plant material and the search for its active principles is limited so far, three major constituents (evodiamine, rutaecarpine, goshuyuamide II) were evaluated for their anti-inflammatory cellular action mechanisms in the present study. From the results, evodiamine and rutaecarpine were found to strongly inhibit prostaglandin E2 synthesis from lipopolysaccharide-treated RAW 264.7 cells at 1-10 μM. Evodiamine inhibited cyclooxygenase-2 induction and NF-κB activation, while rutaecarpine did not. On the other hand, goshuyuamide II inhibited 5-lipoxygenase from RBL-1 cells (IC50 = 6.6 μM), resulting in the reduced synthesis of leukotrienes. However, these three compounds were not inhibitory against inducible nitric oxide synthase-mediated nitric oxide production from RAW cells up to 50 μM. These pharmacological properties may provide the additional scientific rationale for anti-inflammatory use of the fruits of E. rutaecarpa.
Keyword
Anti-inflammationCyclooxygenaseEvodia rutaecarpa Benth (Rutaceae)EvodiamineGoshuyuamideLipoxygenaseRutaecarpine
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02968573
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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