Ureidopyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors

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Title
Ureidopyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors
Author(s)
A Gelain; I Bettinelli; D Barlocco; Byoung-Mog KwonTae Sook Jeong; K R Im; L Legnani; L Toma
Bibliographic Citation
Scientia Pharmaceutica, vol. 74, no. 3, pp. 85-97
Publication Year
2006
Abstract
A series of N-(2,4-difluorophenyl)-N′-heptyl-N′-{4- [(substituted)-pyridazin-3-yl)thio]pentyl}urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate their activity to their structural features.
Keyword
ACAT inhibitorshypercholesterolemiapyridazine derivativesureido derivatives
ISSN
0036-8709
Publisher
?sterreichischer Apothekerverlag
DOI
http://dx.doi.org/10.3797/scipharm.2006.74.85
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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