Histopathological changes of testes and eyes by neutron irradiation with boron compounds in mice = 마우스에 있어서 브론 복합물의 중성자 조사에 의한 정소와 눈의 조직병리학적 변화

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Title
Histopathological changes of testes and eyes by neutron irradiation with boron compounds in mice = 마우스에 있어서 브론 복합물의 중성자 조사에 의한 정소와 눈의 조직병리학적 변화
Author(s)
Y J Kim; Woon Kee Yoon; S Y Ryu; K J Chun; H Y Son; S W Cho
Bibliographic Citation
Journal of Veterinary Science, vol. 7, no. 1, pp. 19-23
Publication Year
2006
Abstract
This study was performed to investigate the biological effects of boron neutron capture therapy (BNCT) on the testes and eyes in mice using HANARO Nuclear Reactor, Korea Atomic Energy Research Institute. BNCT relies on the high capacity of 10B in capturing thermal neutrons. Sodium borocaptate (BSH, 75 ppm, iv) and boronophenylalanine (BPA, 750 ppm, ip) have been used as the boron delivery agents. Mice were irradiated with neutron (flux: 1.036739E +09, Fluence 9.600200E+12) by lying flat pose for 30 (10 Gy) or 100 min (33 Gy) with or without boron carrier treatment. In 45 days of irradiation, histopathological changes of the testes and eyes were examined. Thirty-three Gy neutron irradiation for 100 min induced testicular atrophy in which some of seminiferous tubules showed complete depletion of spermatogenic germ cells. Lens epithelial cells and lens fiber were swollen and showed granular changes in an exposure time dependent manner. However, boron carrier treatment had no significant effect on the lesions. These results suggest that the examination of histopathological changes of lens and testis can be used as "biological dosimeters" for gauging radiation responses and the HANARO Nuclear Reactor has sufficient capacities for the BNCT.
Keyword
BoronEyeHistopathologyNeutron irradiationTestes
ISSN
I000-0131
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4142/jvs.2006.7.1.19
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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