Cytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of lxeris dentata forma albiflora = 세스큐터핀의 세포독성

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dc.contributor.authorE M Ahn-
dc.contributor.authorM H Bang-
dc.contributor.authorM C Song-
dc.contributor.authorM H Park-
dc.contributor.authorH Y Kim-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorN I Baek-
dc.date.accessioned2017-04-19T09:05:41Z-
dc.date.available2017-04-19T09:05:41Z-
dc.date.issued2006-
dc.identifier.issn02536269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7716-
dc.description.abstractIxeris dentata forma albiflora was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O. Eight sesquiterpenes were isolated through repeated silica gel and octadecyl silica gel (C18, ODS) column chromatography of the EtOAc and n-BuOH fractions. Physicochemical analysis using NMR, MS and IR revealed the chemical structures of the sesquiterpenes, which were zaluzanin (1), 9a-hydroxyguaian- 4(15),10(14),11(13)-triene-6,12-olide (2), 3β-O-β-D-glucopyranosyl- 8β-hydroxyguaian-4(15),10(14)-diene-6,12-olide (3), 3-O-β-D- glucopyranosyl-8β-hydroxyguauan-10(14)-ene-6,12-olide (4), ixerin M (5), glucozaluzanin C (6), crepiside I (7), and ixerin D (8). This is the first time that these sesquiterpene lactones have been isolated from this plant. Compounds 1, 2 and 7 revealed relatively high cytotoxicities on human colon carcinoma cell and lung adenocarcinoma cell, while compounds 5 and 7 showed acyl-CoA: cholesterol acyltransferase (ACAT) inhibitory activity.-
dc.publisherPharmaceutical Soc Korea-
dc.titleCytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of lxeris dentata forma albiflora = 세스큐터핀의 세포독성-
dc.title.alternativeCytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of lxeris dentata forma albiflora-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number11-
dc.citation.endPage941-
dc.citation.startPage937-
dc.citation.volume29-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName안은미-
dc.contributor.alternativeName방명호-
dc.contributor.alternativeName송명종-
dc.contributor.alternativeName박미현-
dc.contributor.alternativeName김화영-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName백남인-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 29, no. 11, pp. 937-941-
dc.identifier.doi10.1007/BF02969274-
dc.subject.keywordA549-
dc.subject.keywordACAT-
dc.subject.keywordHT29-
dc.subject.keywordIxeris dentata forma albiflora-
dc.subject.keywordsesquiterpene lactone-
dc.subject.localA549-
dc.subject.localACAT-
dc.subject.localHT29-
dc.subject.localHT-29-
dc.subject.localIxeris dentata forma albiflora-
dc.subject.localsesquiterpene lactone-
dc.description.journalClassY-
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Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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