Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4

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dc.contributor.authorJee Youn Kim-
dc.contributor.authorYeo Dae Yoon-
dc.contributor.authorJi Mi Ahn-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorSong Kyu Park-
dc.contributor.authorKiho Lee-
dc.contributor.authorK B Song-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorSang Bae Han-
dc.date.accessioned2017-04-19T09:05:41Z-
dc.date.available2017-04-19T09:05:41Z-
dc.date.issued2007-
dc.identifier.issn15675769-
dc.identifier.uri10.1016/j.intimp.2006.08.017ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7719-
dc.description.abstractDuring the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently increased the maturation of tlr4+/+ DCs from C57BL/6 and C3H/HeN mice, but not tlr4-/- DCs from C3H/HeJ mice. Phenotypic maturation was confirmed by the elevated expressions of CD80, CD86, and MHC-class II molecules, and functional maturation by increased IL-12 production, enhanced allogenic T cell stimulation, and decreased endocytosis. Angelan was found to activate ERK and NF-κB, which are signaling molecules down-stream of toll-like receptor-4 (TLR4) receptors. Angelan-treated mature DC more effectively inhibited B16F10 tumor growth than immature DCs in syngenic murine tumor model. These results indicate that angelan induces DC maturation via TLR4 signaling pathways and suggest the possible use of angelan in DC-based immunotherapies.-
dc.publisherElsevier-
dc.titleAngelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4-
dc.title.alternativeAngelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number1-
dc.citation.endPage87-
dc.citation.startPage78-
dc.citation.volume7-
dc.contributor.affiliatedAuthorYeo Dae Yoon-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName김지연-
dc.contributor.alternativeName윤여대-
dc.contributor.alternativeName안지미-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName송경빈-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName한상배-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 7, no. 1, pp. 78-87-
dc.identifier.doi10.1016/j.intimp.2006.08.017-
dc.subject.keywordAngelan-
dc.subject.keywordAngelica gigas Nakai-
dc.subject.keywordDendritic cells-
dc.subject.keywordPolysaccharides-
dc.subject.keywordToll-like receptor 4-
dc.subject.localAngelan-
dc.subject.localAngelica gigas Nakai-
dc.subject.localDendritic cells-
dc.subject.localDendritic cell-
dc.subject.localPolysaccharides-
dc.subject.localPolysaccharide-
dc.subject.localToll-like receptor 4-
dc.subject.localToll-like receptor 4 (TLR4)-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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