In silico identification of 6-phosphogluconolactonase genes that are frequently missing from completely sequenced bacterial genomes

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Title
In silico identification of 6-phosphogluconolactonase genes that are frequently missing from completely sequenced bacterial genomes
Author(s)
Haeyoung Jeong; Jihyun Kim; Hong-Seog Park
Bibliographic Citation
Genomics & Informatics, vol. 4, no. 4, pp. 150-155
Publication Year
2006
Abstract
6-Phosphogluconolactonase (6PGL) is one of the key enzymes in the ubiquitous pathways of central carbon metabolism, but bacterial 6PGL had been long known as a missing enzyme even after complete bacterial genome sequence information became available. Although recent experimental characterization suggests that there are two types of 6PGLs (DevB and YbhE), their phylogenetic distribution is severely biased. Here we present that proteins in COG group previously described as 3-carboxymuconate cyclase (COG2706) are actually the YbhE-type 6PGLs, which are widely distributed in Proteobacteria and Firmicutes. This case exemplifies how erroneous functional description of a member in the reference database commonly used in transitive genome annotation cause systematic problem in the prediction of genes even with universal cellular functions.
Keyword
6-phosphogluconolactonase3-carboxymuconatecyclasemissing enzymepentose phosphate pathwaygenome annotation
ISSN
I000-0158
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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