Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum

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Title
Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum
Author(s)
Seung Woong LeeMun Chual Rho; Hye Ran Park; Jung-Ho Choi; Ji Yun Kang; Jung Won Lee; K Kim; Hyun Sun Lee; Young Kook Kim
Bibliographic Citation
Journal of Agricultural and Food Chemistry, vol. 54, no. 26, pp. 9759-9763
Publication Year
2006
Abstract
Pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a potential therapy for the treatment of obesity and type 2 diabetes. Bioassay-guided isolation of CHCl3 extracts of the fruits of Piper longum and Piper nigum (Piperaceae), using an in vitro DGAT inhibitory assay, lead to isolation of a new alkamide named (2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine (2), together with four known alkamides: retrofractamide C (1), pipernonaline (3), piperrolein B (4), and dehydropipernonaline (5). Compounds 2-5 inhibited DGAT with IC50 values of 29.8 (2), 37.2 (3), 20.1 (4), and 21.2 (5) μM, respectively, but the IC50 value for 1 was more than 900 μM. This finding indicates that compounds possessing piperidine groups (2-5) can be potential DGAT inhibitors.
Keyword
AlkamidesDiacylglycerol acyltransferase (DGAT)Piper longumPiper nigrum
ISSN
0021-8561
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/jf061402e
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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