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- Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum
- Seung Woong Lee; Mun Chual Rho; Hye Ran Park; Jung-Ho Choi; Ji Yun Kang; Jung Won Lee; K Kim; Hyun Sun Lee; Young Kook Kim
- Bibliographic Citation
- Journal of Agricultural and Food Chemistry, vol. 54, no. 26, pp. 9759-9763
- Publication Year
- Pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 126.96.36.199) has emerged as a potential therapy for the treatment of obesity and type 2 diabetes. Bioassay-guided isolation of CHCl3 extracts of the fruits of Piper longum and Piper nigum (Piperaceae), using an in vitro DGAT inhibitory assay, lead to isolation of a new alkamide named (2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine (2), together with four known alkamides: retrofractamide C (1), pipernonaline (3), piperrolein B (4), and dehydropipernonaline (5). Compounds 2-5 inhibited DGAT with IC50 values of 29.8 (2), 37.2 (3), 20.1 (4), and 21.2 (5) μM, respectively, but the IC50 value for 1 was more than 900 μM. This finding indicates that compounds possessing piperidine groups (2-5) can be potential DGAT inhibitors.
- AlkamidesDiacylglycerol acyltransferase (DGAT)Piper longumPiper nigrum
- Amer Chem Soc
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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