Dynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells

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dc.contributor.authorD H Kwak-
dc.contributor.authorKweon Yu-
dc.contributor.authorS M Kim-
dc.contributor.authorD H Lee-
dc.contributor.authorS M Kim-
dc.contributor.authorJ U Jung-
dc.contributor.authorJ W Seo-
dc.contributor.authorN Kim-
dc.contributor.authorS Lee-
dc.contributor.authorK Y Jung-
dc.contributor.authorH K You-
dc.contributor.authorH A Kim-
dc.contributor.authorY K Choo-
dc.date.accessioned2017-04-19T09:05:59Z-
dc.date.available2017-04-19T09:05:59Z-
dc.date.issued2006-
dc.identifier.issnI000-0028-
dc.identifier.uri10.1038/emm.2006.79ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7744-
dc.description.abstractStem cells are used for the investigation of developmental processes at both cellular and organism levels and offer tremendous potentials for clinical applications as an unlimited source for transplantation. Gangliosides, sialic acid-conjugated glycosphingolipids, play important regulatory roles in cell proliferation and differentiation. However, their expression patterns in stem cells and during neuronal differentiation are not known. Here, we investigated expression of gangliosides during the growth of mouse embryonic stem cells (mESCs), mesenchymal stem cells (MSCs) and differentiated neuronal cells by using high-performance thin-layer chromatography (HPTLC). Monosialoganglioside 1 (GM1) was expressed in mESCs and MSCs, while GM3 and GD3 were expressed in embryonic bodies. In the 9-day old differentiated neuronal cells from mESCs cells and MSCs, GM1 and GT1b were expressed. Results from immunostaining were consistent with those observed by HPTLC assay. These suggest that gangliosides are specifically expressed according to differentiation of mESCs and MSCs into neuronal cells and expressional difference of gangliosides may be a useful marker to identify differentiation of mESCs and MSCs into neuronal cells.-
dc.publisherSpringer-Nature Pub Group-
dc.titleDynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells-
dc.title.alternativeDynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number6-
dc.citation.endPage676-
dc.citation.startPage668-
dc.citation.volume38-
dc.contributor.affiliatedAuthorKweon Yu-
dc.contributor.alternativeName곽동훈-
dc.contributor.alternativeName유권-
dc.contributor.alternativeName김성민-
dc.contributor.alternativeName이대훈-
dc.contributor.alternativeName김선미-
dc.contributor.alternativeName정지웅-
dc.contributor.alternativeName서정우-
dc.contributor.alternativeName김나리-
dc.contributor.alternativeName이서울-
dc.contributor.alternativeName정규용-
dc.contributor.alternativeName유형근-
dc.contributor.alternativeName김현아-
dc.contributor.alternativeName추영국-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 38, no. 6, pp. 668-676-
dc.identifier.doi10.1038/emm.2006.79-
dc.subject.keywordCell differentiation-
dc.subject.keywordEmbryonic development-
dc.subject.keywordFluorescent antibody techniques-
dc.subject.keywordGangliosides-
dc.subject.keywordMesenchymal stem cells-
dc.subject.keywordStem cells-
dc.subject.localcell differentiation-
dc.subject.localCell differentiation-
dc.subject.localEmbryonic development-
dc.subject.localembryonic development-
dc.subject.localFluorescent antibody techniques-
dc.subject.localGanglioside-
dc.subject.localGangliosides-
dc.subject.localganglioside-
dc.subject.localMesenchymal stem cell-
dc.subject.localmesenchymal stem cells-
dc.subject.localmesenchymal stem cells (MSCs)-
dc.subject.localMesenchymal stem cells-
dc.subject.localstem cells-
dc.subject.localstem cell-
dc.subject.localStem cell-
dc.subject.localStem cells-
dc.subject.localStem Cell-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > 1. Journal Articles
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