Recombination activating genes (RAG) in lymphoma development

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Title
Recombination activating genes (RAG) in lymphoma development
Author(s)
B B Haines; Chun Jeih Ryu; J Chen
Bibliographic Citation
Cell Cycle, vol. 5, no. 9, pp. 913-916
Publication Year
2006
Abstract
The recombination activating genes (RAG) play a central role in the generation of a diverse immune repertoire by mediating DNA recombination events at antigen receptor loci in developing B and T lymphocytes. However, inappropriate RAG activity throughout the genome has been implicated in a large variety of human and mouse lymphomas. Mechanisms by which RAG can provoke or perpetuate lymphoma include deregulation of certain genes by translocation to antigen receptor regulatory regions, the formation of chimeric oncogenes, inactivation of tumor suppressor or micro-RNA loci, or activation of oncogenes. Here we present the T cell receptor enhancer (Eβ) deficient mouse as a tractable in vivo model system to study the role of RAG activity in the context of lymphoma development, and contrast our system with those of others. We posit a general hypothesis that virtually any mutation that impairs early lymphocyte development at stages when RAG is expressed can constitute a pro-carcinogenic event. Our model system provides a means to assess the roles of RAG activity in human lymphoid malignancies.
Keyword
double strand DNA breaklymphomagenesisp53recombination activating gene (RAG)
ISSN
1538-4101
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.4161/cc.5.9.2732
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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