Human endogenous retrovirus (HERV)-R family in primates: chromosomal location, gene expression, and evolution

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dc.contributor.authorH S Kim-
dc.contributor.authorJ M Yi-
dc.contributor.authorH Hirai-
dc.contributor.authorJae Won Huh-
dc.contributor.authorM S Jeong-
dc.contributor.authorS B Jang-
dc.contributor.authorC G Kim-
dc.contributor.authorN Saitou-
dc.contributor.authorByung Hwa Hyun-
dc.contributor.authorW H Lee-
dc.date.accessioned2017-04-19T09:06:28Z-
dc.date.available2017-04-19T09:06:28Z-
dc.date.issued2006-
dc.identifier.issn0378-1119-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7755-
dc.description.abstractHitherto, full-length endogenous retrovirus (HERV)-R has been located at human chromosome 7q11.2, and mRNA and envelope proteins have been detected in placenta and a variety of other cell types. In the present study, using a probe derived from the gorilla fosmid library, we detected the paralogous locus (7q31.3) of the HERV-R env gene in human chromosome 7q11.2, and also determined the chromosomal location in apes and Old World monkeys. The HERV-R gene was not detected in New World monkeys or prosimians with FISH and PCR analyses. We determined the sequences of the HERV-R env genes obtained from the genomic DNA of primates using PCR and sequencing tools. Except for a HERV-R env sequence derived from gorilla DNA, the functional domains of putative envelope proteins are conserved, suggesting that those domains could have a functional capacity in the primate genome. In addition, we investigated the env gene expression of HERV-R in various human tissues and cancer cells. An RT-PCR approach indicated that the env gene was expressed in several human tissues (brain, prostate, testis, kidney, placenta, thymus, and uterus) and cancer cells (RT4, BT-474, MCF7, OVCAR-3, LOX-IMVI, and AZ521). Taken together, our data could be of great use for understanding the evolutionary dynamics of HERV-R through primate radiation as well as the implications of its functional role in human tissues and cancers cells.-
dc.publisherElsevier-
dc.titleHuman endogenous retrovirus (HERV)-R family in primates: chromosomal location, gene expression, and evolution-
dc.title.alternativeHuman endogenous retrovirus (HERV)-R family in primates: chromosomal location, gene expression, and evolution-
dc.typeArticle-
dc.citation.titleGene-
dc.citation.number0-
dc.citation.endPage42-
dc.citation.startPage34-
dc.citation.volume370-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorByung Hwa Hyun-
dc.contributor.alternativeName김희수-
dc.contributor.alternativeName이주미-
dc.contributor.alternativeNameHirai-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName정미숙-
dc.contributor.alternativeName장세복-
dc.contributor.alternativeName김충곤-
dc.contributor.alternativeNameSaitou-
dc.contributor.alternativeName현병화-
dc.contributor.alternativeName이원호-
dc.identifier.bibliographicCitationGene, vol. 370, pp. 34-42-
dc.identifier.doi10.1016/j.gene.2005.11.008-
dc.subject.keywordCancer cells-
dc.subject.keywordExpression-
dc.subject.keywordFISH-
dc.subject.keywordHERV-R-
dc.subject.keywordHuman tissues-
dc.subject.keywordPrimates-
dc.subject.localcancer cell-
dc.subject.localCancer cells-
dc.subject.localCancer cell-
dc.subject.localexpression-
dc.subject.localExpression-
dc.subject.localFISH-
dc.subject.localFish-
dc.subject.localHERV-R-
dc.subject.localhuman tissue-
dc.subject.localHuman tissues-
dc.subject.localHuman tissue-
dc.subject.localprimate-
dc.subject.localPrimates-
dc.subject.localPrimate-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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