DC Field | Value | Language |
---|---|---|
dc.contributor.author | H S Kim | - |
dc.contributor.author | J M Yi | - |
dc.contributor.author | H Hirai | - |
dc.contributor.author | Jae Won Huh | - |
dc.contributor.author | M S Jeong | - |
dc.contributor.author | S B Jang | - |
dc.contributor.author | C G Kim | - |
dc.contributor.author | N Saitou | - |
dc.contributor.author | Byung Hwa Hyun | - |
dc.contributor.author | W H Lee | - |
dc.date.accessioned | 2017-04-19T09:06:28Z | - |
dc.date.available | 2017-04-19T09:06:28Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0378-1119 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7755 | - |
dc.description.abstract | Hitherto, full-length endogenous retrovirus (HERV)-R has been located at human chromosome 7q11.2, and mRNA and envelope proteins have been detected in placenta and a variety of other cell types. In the present study, using a probe derived from the gorilla fosmid library, we detected the paralogous locus (7q31.3) of the HERV-R env gene in human chromosome 7q11.2, and also determined the chromosomal location in apes and Old World monkeys. The HERV-R gene was not detected in New World monkeys or prosimians with FISH and PCR analyses. We determined the sequences of the HERV-R env genes obtained from the genomic DNA of primates using PCR and sequencing tools. Except for a HERV-R env sequence derived from gorilla DNA, the functional domains of putative envelope proteins are conserved, suggesting that those domains could have a functional capacity in the primate genome. In addition, we investigated the env gene expression of HERV-R in various human tissues and cancer cells. An RT-PCR approach indicated that the env gene was expressed in several human tissues (brain, prostate, testis, kidney, placenta, thymus, and uterus) and cancer cells (RT4, BT-474, MCF7, OVCAR-3, LOX-IMVI, and AZ521). Taken together, our data could be of great use for understanding the evolutionary dynamics of HERV-R through primate radiation as well as the implications of its functional role in human tissues and cancers cells. | - |
dc.publisher | Elsevier | - |
dc.title | Human endogenous retrovirus (HERV)-R family in primates: chromosomal location, gene expression, and evolution | - |
dc.title.alternative | Human endogenous retrovirus (HERV)-R family in primates: chromosomal location, gene expression, and evolution | - |
dc.type | Article | - |
dc.citation.title | Gene | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 42 | - |
dc.citation.startPage | 34 | - |
dc.citation.volume | 370 | - |
dc.contributor.affiliatedAuthor | Jae Won Huh | - |
dc.contributor.affiliatedAuthor | Byung Hwa Hyun | - |
dc.contributor.alternativeName | 김희수 | - |
dc.contributor.alternativeName | 이주미 | - |
dc.contributor.alternativeName | Hirai | - |
dc.contributor.alternativeName | 허재원 | - |
dc.contributor.alternativeName | 정미숙 | - |
dc.contributor.alternativeName | 장세복 | - |
dc.contributor.alternativeName | 김충곤 | - |
dc.contributor.alternativeName | Saitou | - |
dc.contributor.alternativeName | 현병화 | - |
dc.contributor.alternativeName | 이원호 | - |
dc.identifier.bibliographicCitation | Gene, vol. 370, pp. 34-42 | - |
dc.identifier.doi | 10.1016/j.gene.2005.11.008 | - |
dc.subject.keyword | Cancer cells | - |
dc.subject.keyword | Expression | - |
dc.subject.keyword | FISH | - |
dc.subject.keyword | HERV-R | - |
dc.subject.keyword | Human tissues | - |
dc.subject.keyword | Primates | - |
dc.subject.local | cancer cell | - |
dc.subject.local | Cancer cells | - |
dc.subject.local | Cancer cell | - |
dc.subject.local | expression | - |
dc.subject.local | Expression | - |
dc.subject.local | FISH | - |
dc.subject.local | Fish | - |
dc.subject.local | HERV-R | - |
dc.subject.local | human tissue | - |
dc.subject.local | Human tissues | - |
dc.subject.local | Human tissue | - |
dc.subject.local | primate | - |
dc.subject.local | Primates | - |
dc.subject.local | Primate | - |
dc.description.journalClass | Y | - |
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