Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae

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dc.contributor.authorC J Zheng-
dc.contributor.authorMi Jin Sohn-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2017-04-19T09:06:30Z-
dc.date.available2017-04-19T09:06:30Z-
dc.date.issued2006-
dc.identifier.issn0021-8820-
dc.identifier.uri10.1038/ja.2006.108ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7763-
dc.description.abstractTwo potent inhibitors of FabK, the enoyl-acyl carrier protein (ACP) reductase of Streptococcus pneumoniae, were isolated from the solid state fermentation of an unidentified fungus F010248. Their structures were identified to be atromentin and leucomelone by various spectral analysis. Atromentin and leucomelone inhibited the FabK with IC50 values of 0.24 and 1.57 μM, respectively, while did not inhibit FabI, the enoyl-ACP reductase of either Escherichia coli or Staphylococcus aureus, even at 200 μM. Atromentin and leucomelone are the first inhibitors specific to the enoyl-ACP reductase (FabK) of Streptococcus pneumoniae.-
dc.publisherSpringer-Nature Pub Group-
dc.titleAtromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae-
dc.title.alternativeAtromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae-
dc.typeArticle-
dc.citation.titleJournal of Antibiotics-
dc.citation.number12-
dc.citation.endPage812-
dc.citation.startPage808-
dc.citation.volume59-
dc.contributor.affiliatedAuthorMi Jin Sohn-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeNameZheng-
dc.contributor.alternativeName손미진-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationJournal of Antibiotics, vol. 59, no. 12, pp. 808-812-
dc.identifier.doi10.1038/ja.2006.108-
dc.subject.keywordAtromentin-
dc.subject.keywordEnoyl-ACP reductase-
dc.subject.keywordFabK-
dc.subject.keywordLeucomelone-
dc.subject.keywordStreptococcus pneumoniae-
dc.subject.keywordTerphenyl-
dc.subject.localAtromentin-
dc.subject.localEnoyl-ACP reductase-
dc.subject.localenoyl-ACP reductase-
dc.subject.localFabK-
dc.subject.localLeucomelone-
dc.subject.localStreptococcus pneumoniae-
dc.subject.localTerphenyl-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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