2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells = 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid 처리에 의한 인간 간암세포주 HepG2의 apoptosis 유도

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dc.contributor.authorK H Yoo-
dc.contributor.authorJ M Lee-
dc.contributor.authorJ Hwang-Bo-
dc.contributor.authorM C Song-
dc.contributor.authorH J Yang-
dc.contributor.authorN I Baek-
dc.contributor.authorS H Kim-
dc.contributor.authorD K Kim-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorM H Park-
dc.contributor.authorI S Chung-
dc.date.accessioned2017-04-19T09:06:33Z-
dc.date.available2017-04-19T09:06:33Z-
dc.date.issued2006-
dc.identifier.issnI000-0171-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7783-
dc.description.abstract2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid was isolated from Trapa pseudoincisa S. et Z. It has a common structure of pentacyclic triterpenes and belongs to the amyrin ursolic acid group. The cytotoxic effect of this compound was investigated in human hepatoma cell line HepG2. 2β, 3α, 23- trihydroxyrus-12-ene-28-oic acid showed dose-dependent cytotoxicity in HepG2 cells. Confocal microscopy data showed that green fluorescence was increased in 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid treated-HepG2 cells in a time-dependent manner. 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid also increased the sub-G1 cell population of HepG2 cells as well as ladder-like DNA fragmentation. Taken together, our results indicate that 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induced apoptosis in HepG2 cells.-
dc.publisherKorea Soc-Assoc-Inst-
dc.title2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells = 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid 처리에 의한 인간 간암세포주 HepG2의 apoptosis 유도-
dc.title.alternative2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells-
dc.typeArticle-
dc.citation.titleJournal of Korean Society for Applied Biological Chemistry-
dc.citation.number4-
dc.citation.endPage275-
dc.citation.startPage270-
dc.citation.volume49-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName유기현-
dc.contributor.alternativeName이종민-
dc.contributor.alternativeName황보전-
dc.contributor.alternativeName송명종-
dc.contributor.alternativeName양혜정-
dc.contributor.alternativeName백남인-
dc.contributor.alternativeName김성훈-
dc.contributor.alternativeName김대근-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName박미현-
dc.contributor.alternativeName정인식-
dc.identifier.bibliographicCitationJournal of Korean Society for Applied Biological Chemistry, vol. 49, no. 4, pp. 270-275-
dc.subject.keyword-
dc.subject.keyword-
dc.subject.keyword23-trihydroxyrus-12-ene-28-oic acid-
dc.subject.keywordHepG2-
dc.subject.keywordapoptosis-
dc.subject.keywordcytotoxicity-
dc.subject.local-
dc.subject.local-
dc.subject.local23-trihydroxyrus-12-ene-28-oic acid-
dc.subject.localHepG2-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.description.journalClassN-
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