2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells = 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid 처리에 의한 인간 간암세포주 HepG2의 apoptosis 유도
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | K H Yoo | - |
| dc.contributor.author | J M Lee | - |
| dc.contributor.author | J Hwang-Bo | - |
| dc.contributor.author | M C Song | - |
| dc.contributor.author | H J Yang | - |
| dc.contributor.author | N I Baek | - |
| dc.contributor.author | S H Kim | - |
| dc.contributor.author | D K Kim | - |
| dc.contributor.author | Byoung-Mog Kwon | - |
| dc.contributor.author | M H Park | - |
| dc.contributor.author | I S Chung | - |
| dc.date.accessioned | 2017-04-19T09:06:33Z | - |
| dc.date.available | 2017-04-19T09:06:33Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.issn | I000-0171 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7783 | - |
| dc.description.abstract | 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid was isolated from Trapa pseudoincisa S. et Z. It has a common structure of pentacyclic triterpenes and belongs to the amyrin ursolic acid group. The cytotoxic effect of this compound was investigated in human hepatoma cell line HepG2. 2β, 3α, 23- trihydroxyrus-12-ene-28-oic acid showed dose-dependent cytotoxicity in HepG2 cells. Confocal microscopy data showed that green fluorescence was increased in 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid treated-HepG2 cells in a time-dependent manner. 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid also increased the sub-G1 cell population of HepG2 cells as well as ladder-like DNA fragmentation. Taken together, our results indicate that 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induced apoptosis in HepG2 cells. | - |
| dc.publisher | Korea Soc-Assoc-Inst | - |
| dc.title | 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells = 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid 처리에 의한 인간 간암세포주 HepG2의 apoptosis 유도 | - |
| dc.title.alternative | 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Korean Society for Applied Biological Chemistry | - |
| dc.citation.number | 4 | - |
| dc.citation.endPage | 275 | - |
| dc.citation.startPage | 270 | - |
| dc.citation.volume | 49 | - |
| dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
| dc.contributor.alternativeName | 유기현 | - |
| dc.contributor.alternativeName | 이종민 | - |
| dc.contributor.alternativeName | 황보전 | - |
| dc.contributor.alternativeName | 송명종 | - |
| dc.contributor.alternativeName | 양혜정 | - |
| dc.contributor.alternativeName | 백남인 | - |
| dc.contributor.alternativeName | 김성훈 | - |
| dc.contributor.alternativeName | 김대근 | - |
| dc.contributor.alternativeName | 권병목 | - |
| dc.contributor.alternativeName | 박미현 | - |
| dc.contributor.alternativeName | 정인식 | - |
| dc.identifier.bibliographicCitation | Journal of Korean Society for Applied Biological Chemistry, vol. 49, no. 4, pp. 270-275 | - |
| dc.subject.keyword | 2β | - |
| dc.subject.keyword | 3α | - |
| dc.subject.keyword | 23-trihydroxyrus-12-ene-28-oic acid | - |
| dc.subject.keyword | HepG2 | - |
| dc.subject.keyword | apoptosis | - |
| dc.subject.keyword | cytotoxicity | - |
| dc.subject.local | 2β | - |
| dc.subject.local | 3α | - |
| dc.subject.local | 23-trihydroxyrus-12-ene-28-oic acid | - |
| dc.subject.local | HepG2 | - |
| dc.subject.local | apoptosis | - |
| dc.subject.local | Apoptosis | - |
| dc.subject.local | Cytotoxicity | - |
| dc.subject.local | cytotoxicity | - |
| dc.description.journalClass | N | - |
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