Embellistatin, a microtubule polymerization inhibitor, inhibits angiogenesis both in vitro and in vivo

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Title
Embellistatin, a microtubule polymerization inhibitor, inhibits angiogenesis both in vitro and in vivo
Author(s)
H J Jung; J S Shim; H B Lee; Chang-Jin Kim; T Kuwano; M Ono; H J Kwon
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 353, no. 2, pp. 376-380
Publication Year
2007
Abstract
The efficient inhibition of angiogenesis is considered as a promising strategy for the treatment of angiogenesis-related diseases including cancer. Herein, we report that embellistatin, a bicyclic ketone compound known as a microtubule polymerization inhibitor, exhibits anti-angiogenic activity. Embellistatin inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced invasion and tube formation as well as bFGF-induced mouse corneal angiogenesis in vivo. Notably, embellistatin exhibited stronger inhibition activity for the growth of BAECs than that of normal and cancer cell lines. Cell cycle analysis revealed that the compound arrests cell cycle at G2/M phase, which is associated with the increased expression of p21WAF1 and p53 partly. These results demonstrate that embellistatin may serve the basis for the development of new anti-angiogenic agents.
Keyword
Anti-angiogenic agentAnti-microtubule agentCell cycle arrestEmbellisia chlamydosporaEmbellistatin
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2006.12.026
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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