The expression of estrogen receptors in hepatocellular carcinoma in Korean patients

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Title
The expression of estrogen receptors in hepatocellular carcinoma in Korean patients
Author(s)
A G Wang; K Y Lee; S Y Kim; J Y Choi; K H Lee; W H Kim; H J Wang; J M Kim; M G Park; Young Il YeomNam-Soon Kim; Dae Yeul Yu; Dong Seok Lee
Bibliographic Citation
Yonsei Medical Journal, vol. 47, no. 6, pp. 811-816
Publication Year
2006
Abstract
Expression of estrogen receptors (ER)-α and -β, as well as androgen receptor (AR), in hepatocellular carcinoma (HCC) is thought to be correlated with prognosis, survival, and male prevalence of HCC. These hypotheses are based on investigations of European patients; however the expression patterns of these receptors in Asian patients are largely unknown. In this study, we collected liver carcinoma and peritumor tissues from 32 patients (9 females and 23 males) in South Korea. The expression of ERs and ARs was studied using RT-PCR. Wild-type ER-α and AR were expressed in all of the samples investigated, and their expression was independent of the causal virus or patient sex. Expression of the ER-α variant was independent of sex (100% female vs. 91.3% male) and HCV and HBV status (91.3% vs. 100%). Wild-type ER-β was expressed more often in HCV patients than in HBV patients (95.7% vs. 44.4%; p < 0.05). In conclusion, the stronger ER-α variant expression in HCC tissues implies that this variant has an important role in HCC development. However, at least in Korean patients, expression of the ER-α variant (vER-α) is not related to male HCC prevalence. In addition, the predominant expression of ER-β in HCV patients suggests that it plays an important role in HCV-induced liver disease.
Keyword
Androgen receptorEstrogen receptor-αHepatitis B virusHepatitis C virusHepatocellular carcinoma
ISSN
0513-5796
Publisher
Yonsei Univ Coll Medicine
DOI
http://dx.doi.org/10.3349/ymj.2006.47.6.811
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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