SRF is a nuclear repressor of Smad3-mediated TGF-beta signaling = SRF의 Smad3-mediated TGF 신호전달에서의 핵내억제 작용

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Title
SRF is a nuclear repressor of Smad3-mediated TGF-beta signaling = SRF의 Smad3-mediated TGF 신호전달에서의 핵내억제 작용
Author(s)
Ho Jae Lee; C H Yun; S H Lim; B C Kim; K G Baik; J M Kim; W H Kim; S J Kim
Bibliographic Citation
Oncogene, vol. 26, no. 2, pp. 173-185
Publication Year
2007
Abstract
Serum response factor (SRF) is a widely expressed transcription factor involved in immediate-early and tissue-specific gene expression, cell proliferation and differentiation. We defined a new role of SRF as a nuclear repressor of the tumor growth factor β1 (TGF-β1) growth-inhibitory signal during cell proliferation. We show that SRF significantly inhibits the TGF-β1/Smad-dependent transcription by associating with Smad3. SRF causes resistance to the TGF-β1 cytostatic response by directly repressing the Smad transcriptional activity and Smad binding to DNA. Furthermore, we demonstrated that overexpression of SRF markedly decreases the level of Smad3 complex binding to the promoters of Smad3 target genes, p15INK4b and p21Cip1. This leads to the inhibition of expression of TGF-β1-responsive genes. SRF therefore acts as a nuclear repressor of Smad3-mediated TGF-β1 signaling.
Keyword
signalingsmadSRFsuppressionTGF-βtranscription
ISSN
0950-9232
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/sj.onc.1209774
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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