The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells

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dc.contributor.authorH Y Yang-
dc.contributor.authorS H Kim-
dc.contributor.authorSeok Ho Kim-
dc.contributor.authorDong-Jun Kim-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorD S Lee-
dc.contributor.authorY J Kim-
dc.contributor.authorB J Park-
dc.contributor.authorT H Lee-
dc.date.accessioned2017-04-19T09:06:41Z-
dc.date.available2017-04-19T09:06:41Z-
dc.date.issued2007-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2006.12.155ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7810-
dc.description.abstractErythropoiesis is a complex multistage process for the differentiation of mature erythrocytes from hematopoietic stem cells. The function of several transcription factors has been reported in hematopoietic stem cell differentiation. However, the molecular basis governing its functional behavior is unclear. In this study, we characterized the role of Zfpm-1 during the erythropoietic differentiation of human hematopoietic stem cells. To verify the function of Zfpm-1 during erythropoietic differentiation, we established human CD34+ cell culture system by using human umbilical cord blood. At day 7 of the human CD34+ cell differentiation process to proerythocytes, Zfpm-1 was initially up-regulated and then dramatically down-regulated at day 9. The Zfpm-1 siRNA transfected HSCs contained 20% more GPA+ cells than the mock transfected cells, and showed repressed expression of the hematopoietic transcription factors, c-myc and c-myb, but increased expression of GATA-1. In contrast, the Zfpm-1 gain-of-function is the opposite of loss-of-function results above.-
dc.publisherElsevier-
dc.titleThe suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells-
dc.title.alternativeThe suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number4-
dc.citation.endPage984-
dc.citation.startPage978-
dc.citation.volume353-
dc.contributor.affiliatedAuthorSeok Ho Kim-
dc.contributor.affiliatedAuthorDong-Jun Kim-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.alternativeName양희영-
dc.contributor.alternativeName김수희-
dc.contributor.alternativeName김석호-
dc.contributor.alternativeName김동준-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName이동석-
dc.contributor.alternativeName김용준-
dc.contributor.alternativeName박병주-
dc.contributor.alternativeName이태훈-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 353, no. 4, pp. 978-984-
dc.identifier.doi10.1016/j.bbrc.2006.12.155-
dc.subject.keywordc-myb-
dc.subject.keywordc-myc-
dc.subject.keyworderythropoiesis-
dc.subject.keywordGATA-1-
dc.subject.keywordhematopoietic stem cell-
dc.subject.keywordZfpm-1-
dc.subject.keywordZfpm-2-
dc.subject.localc-myb-
dc.subject.localc-myc-
dc.subject.localc-Myc-
dc.subject.localC-MYC-
dc.subject.localC-Myc-
dc.subject.localErythropoiesis-
dc.subject.localerythropoiesis-
dc.subject.localGATA-1-
dc.subject.localGATA1-
dc.subject.localHematopoietic stem cell-
dc.subject.localhematopoietic stem cell-
dc.subject.localHematopoietic stem cells-
dc.subject.localZfpm-1-
dc.subject.localZfpm-2-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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