DC Field | Value | Language |
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dc.contributor.author | Tae Hoon Kang | - |
dc.contributor.author | E I Hwang | - |
dc.contributor.author | Bong Sik Yun | - |
dc.contributor.author | K D Park | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.contributor.author | C S Shin | - |
dc.contributor.author | Sung Uk Kim | - |
dc.date.accessioned | 2017-04-19T09:06:43Z | - |
dc.date.available | 2017-04-19T09:06:43Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | 10.1248/bpb.30.598 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7821 | - |
dc.description.abstract | In the course of search for potent chitin synthase inhibitors from natural resources, a novel chitin synthases inhibitor, 2′-benzoyloxycinnamaldehyde (2′-BCA) (I), was isolated from the aerial parts of Pleuropterus ciliinervis NAKAI. 2′-BCA inhibited chitin synthase 1 and 2 of Saccharomyces cerevisiae with the IC50s of 54.9 and 70.8 μg/ml, respectively, whereas it exhibited no inhibitory activity for chitin synthase 3 up to 280 μg/ml. Its derivatives, 2′-chloro- (V) and 2(-bromo-cinnamaldehyde (VI), each showed 1.9 and 2.7-fold stronger inhibitory activities than 2′-BCA, with the IC50s of 37.2 and 26.6 μg/ml, respectively. Especially, the IC50 of compound VI against chitin synthase 2 represented 1.7-fold more potent inhibitory activity than polyoxin D, a well-known chitin synthase inhibitor. Furthermore, compounds V and VI showed potent antifungal activities against various fungi including human pathogenic fungi, with a particularly strong inhibitory activity against Cryptococcus neoformans (MIC=16 μg/ml). Although the chemical synthesis of this compound has been reported, the present study is the first report to describe the isolation of 2′-BCA from natural resources and chitin synthases inhibitory activities of its derivatives. These results suggested that 2′-BCA and its derivatives can potentially serve as useful lead compounds for development of antifungal agents. | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | Inhibition of chitin synthases and antifungal activities by 2'-benzoyloxycinnamaldehyde from Pleuropterus ciliinervis and its derivatives | - |
dc.title.alternative | Inhibition of chitin synthases and antifungal activities by 2'-benzoyloxycinnamaldehyde from Pleuropterus ciliinervis and its derivatives | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 602 | - |
dc.citation.startPage | 598 | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Tae Hoon Kang | - |
dc.contributor.affiliatedAuthor | Bong Sik Yun | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.affiliatedAuthor | Sung Uk Kim | - |
dc.contributor.alternativeName | 강태훈 | - |
dc.contributor.alternativeName | 황의일 | - |
dc.contributor.alternativeName | 윤봉식 | - |
dc.contributor.alternativeName | 박기덕 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.contributor.alternativeName | 신철수 | - |
dc.contributor.alternativeName | 김성욱 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 30, no. 3, pp. 598-602 | - |
dc.identifier.doi | 10.1248/bpb.30.598 | - |
dc.subject.keyword | 2′-benzoyloxycinnamaldehyde | - |
dc.subject.keyword | Antifungal activity | - |
dc.subject.keyword | Chitin synthase inhibitor | - |
dc.subject.keyword | Pleuropterus ciliinervis | - |
dc.subject.local | 2'-Benzoyloxycinnamaldehyde (BCA) | - |
dc.subject.local | 2'-Benzoyloxycinnamaldehyde | - |
dc.subject.local | 2′-benzoyloxycinnamaldehyde | - |
dc.subject.local | Antifungal activity | - |
dc.subject.local | Anti-fungal activity | - |
dc.subject.local | antifungal activity | - |
dc.subject.local | Chitin synthase inhibitor | - |
dc.subject.local | pleuropterus ciliinervis | - |
dc.subject.local | Pleuropterus ciliinervis | - |
dc.description.journalClass | Y | - |
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