ACAT inhibition of alkamides identified in the fruits of Piper nigrum
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Mun Chual Rho | - |
| dc.contributor.author | Seung Woong Lee | - |
| dc.contributor.author | Hye Ran Park | - |
| dc.contributor.author | Jung Ho Choi | - |
| dc.contributor.author | Ji Yun Kang | - |
| dc.contributor.author | K Kim | - |
| dc.contributor.author | Hyun Sun Lee | - |
| dc.contributor.author | Young Kook Kim | - |
| dc.date.accessioned | 2017-04-19T09:06:46Z | - |
| dc.date.available | 2017-04-19T09:06:46Z | - |
| dc.date.issued | 2007 | - |
| dc.identifier.issn | 0031-9422 | - |
| dc.identifier.uri | 10.1016/j.phytochem.2006.11.025 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7832 | - |
| dc.description.abstract | In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated. Their structures were elucidated via spectroscopic analysis (1H, 13C NMR and ESI-MS), as follows: retrofractamide A (1), pipercide (2), piperchabamide D (3), pellitorin (4), dehydroretrofractamide C (5) and dehydropipernonaline (6). The IC50 values determined for the compounds were 24.5 (1), 3.7 (2), 13.5 (3), 40.5 (4), 60 (5) and 90 μM (6), according to the results of an ACAT enzyme assay system using rat liver microsomes. These compounds all inhibited cholesterol esterification in HepG2 cells. | - |
| dc.publisher | Elsevier | - |
| dc.title | ACAT inhibition of alkamides identified in the fruits of Piper nigrum | - |
| dc.title.alternative | ACAT inhibition of alkamides identified in the fruits of Piper nigrum | - |
| dc.type | Article | - |
| dc.citation.title | Phytochemistry | - |
| dc.citation.number | 6 | - |
| dc.citation.endPage | 903 | - |
| dc.citation.startPage | 899 | - |
| dc.citation.volume | 68 | - |
| dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
| dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
| dc.contributor.affiliatedAuthor | Hye Ran Park | - |
| dc.contributor.affiliatedAuthor | Jung Ho Choi | - |
| dc.contributor.affiliatedAuthor | Ji Yun Kang | - |
| dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
| dc.contributor.affiliatedAuthor | Young Kook Kim | - |
| dc.contributor.alternativeName | 노문철 | - |
| dc.contributor.alternativeName | 이승웅 | - |
| dc.contributor.alternativeName | 박혜란 | - |
| dc.contributor.alternativeName | 최정호 | - |
| dc.contributor.alternativeName | 강지윤 | - |
| dc.contributor.alternativeName | 김관회 | - |
| dc.contributor.alternativeName | 이현선 | - |
| dc.contributor.alternativeName | 김영국 | - |
| dc.identifier.bibliographicCitation | Phytochemistry, vol. 68, no. 6, pp. 899-903 | - |
| dc.identifier.doi | 10.1016/j.phytochem.2006.11.025 | - |
| dc.subject.keyword | Acyl CoA: cholesterol acyltransferase (ACAT) | - |
| dc.subject.keyword | Alkamides | - |
| dc.subject.keyword | Atherosclerosis | - |
| dc.subject.keyword | Cellular cholesterol esterification | - |
| dc.subject.keyword | HepG2 cells | - |
| dc.subject.keyword | Piper nigum L. | - |
| dc.subject.keyword | Piperaceae | - |
| dc.subject.local | ACAT (acyl-CoA: cholesterol acyltransferase) | - |
| dc.subject.local | Acyl-CoA:cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | cholesterol acytransferase (ACAT) | - |
| dc.subject.local | Cholestrol Acyl Transferase (ACAT) | - |
| dc.subject.local | Acyl CoA: cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | ACAT (Acyl-CoA:cholesterol acyltransferase) | - |
| dc.subject.local | Acyl-CoA:cholesterol acyltransferase | - |
| dc.subject.local | ACAT | - |
| dc.subject.local | Acyl-CoA: cholesterol acyltransferase | - |
| dc.subject.local | acyl-CoA:cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | Acyl-CoA: cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | Cholesterol acytransferase (ACAT) | - |
| dc.subject.local | cholestrol acyl transferase (ACAT) | - |
| dc.subject.local | Alkamides | - |
| dc.subject.local | atherosclerosis | - |
| dc.subject.local | Atherosclerosis | - |
| dc.subject.local | atheroclerosis | - |
| dc.subject.local | Cellular cholesterol esterification | - |
| dc.subject.local | HepG2 cells | - |
| dc.subject.local | HepG2 cell | - |
| dc.subject.local | Piper nigrum | - |
| dc.subject.local | Piper nigum L. | - |
| dc.subject.local | Piperaceae | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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