Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

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Title
Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi
Author(s)
N Kim; J C Shin; Won Cheol Kim; B Y Hwang; B S Kim; Young-Soo Hong; D Lee
Bibliographic Citation
Journal of Antibiotics, vol. 59, no. 12, pp. 797-800
Publication Year
2006
Abstract
Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 μg/ml, respectively.
Keyword
Alkysalicylic acidCytotoxicStreptomyces
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ja.2006.105
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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