Glabrol, an acyl-coenzyme A: Cholesterol acyltransferase inhibitor from licorice roots
Cited 15 time in 
Metadata Downloads
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jung Ho Choi | - |
| dc.contributor.author | Mun Chual Rho | - |
| dc.contributor.author | Seung Woong Lee | - |
| dc.contributor.author | O E Kwon | - |
| dc.contributor.author | Hye Ran Park | - |
| dc.contributor.author | Ji Yun Kang | - |
| dc.contributor.author | S H Lee | - |
| dc.contributor.author | Hyun Sun Lee | - |
| dc.contributor.author | K H Bae | - |
| dc.contributor.author | Young Kook Kim | - |
| dc.date.accessioned | 2017-04-19T09:06:47Z | - |
| dc.date.available | 2017-04-19T09:06:47Z | - |
| dc.date.issued | 2007 | - |
| dc.identifier.issn | 0378-8741 | - |
| dc.identifier.uri | 10.1016/j.jep.2006.10.012 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7836 | - |
| dc.description.abstract | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One isoprenyl flavonoid was isolated from ethanol extract of licorice roots. On the basis of spectral evidences, the compound was identified as glabrol (1). Compound 1 inhibited rat liver microsomal ACAT activity with an IC50 value of 24.6 μM and decreased cholesteryl ester formation with an IC50 value of 26.0 μM in HepG2 cells. In addition, 1 showed a non-competitive type of inhibition against ACAT. | - |
| dc.publisher | Elsevier | - |
| dc.title | Glabrol, an acyl-coenzyme A: Cholesterol acyltransferase inhibitor from licorice roots | - |
| dc.title.alternative | Glabrol, an acyl-coenzyme A: Cholesterol acyltransferase inhibitor from licorice roots | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Ethnopharmacology | - |
| dc.citation.number | 3 | - |
| dc.citation.endPage | 566 | - |
| dc.citation.startPage | 563 | - |
| dc.citation.volume | 110 | - |
| dc.contributor.affiliatedAuthor | Jung Ho Choi | - |
| dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
| dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
| dc.contributor.affiliatedAuthor | Hye Ran Park | - |
| dc.contributor.affiliatedAuthor | Ji Yun Kang | - |
| dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
| dc.contributor.affiliatedAuthor | Young Kook Kim | - |
| dc.contributor.alternativeName | 최정호 | - |
| dc.contributor.alternativeName | 노문철 | - |
| dc.contributor.alternativeName | 이승웅 | - |
| dc.contributor.alternativeName | 권오억 | - |
| dc.contributor.alternativeName | 박혜란 | - |
| dc.contributor.alternativeName | 강지윤 | - |
| dc.contributor.alternativeName | 이승호 | - |
| dc.contributor.alternativeName | 이현선 | - |
| dc.contributor.alternativeName | 배기환 | - |
| dc.contributor.alternativeName | 김영국 | - |
| dc.identifier.bibliographicCitation | Journal of Ethnopharmacology, vol. 110, no. 3, pp. 563-566 | - |
| dc.identifier.doi | 10.1016/j.jep.2006.10.012 | - |
| dc.subject.keyword | Acyl-CoA: cholesterol acyltransferase | - |
| dc.subject.keyword | Atherosclerosis | - |
| dc.subject.keyword | Hypocholesterolemia | - |
| dc.subject.keyword | Licorice | - |
| dc.subject.local | ACAT (acyl-CoA: cholesterol acyltransferase) | - |
| dc.subject.local | Acyl-CoA:cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | cholesterol acytransferase (ACAT) | - |
| dc.subject.local | Cholestrol Acyl Transferase (ACAT) | - |
| dc.subject.local | Acyl CoA: cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | ACAT (Acyl-CoA:cholesterol acyltransferase) | - |
| dc.subject.local | Acyl-CoA:cholesterol acyltransferase | - |
| dc.subject.local | ACAT | - |
| dc.subject.local | Acyl-CoA: cholesterol acyltransferase | - |
| dc.subject.local | acyl-CoA:cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | Acyl-CoA: cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | Acyl-coenzyme A: cholesterol acyltransferase (ACAT) | - |
| dc.subject.local | Cholesterol acytransferase (ACAT) | - |
| dc.subject.local | cholestrol acyl transferase (ACAT) | - |
| dc.subject.local | atherosclerosis | - |
| dc.subject.local | Atherosclerosis | - |
| dc.subject.local | atheroclerosis | - |
| dc.subject.local | Hypocholesterolemia | - |
| dc.subject.local | Licorice | - |
| dc.subject.local | licorice | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.