Biosynthesis of bile acids in a variety of marine bacterial taxa

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Title
Biosynthesis of bile acids in a variety of marine bacterial taxa
Author(s)
D Kim; Jong Suk Lee; J Kim; So Jung Kang; Jung-Hoon Yoon; Won Gon Kim; C H Lee
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 17, no. 3, pp. 403-407
Publication Year
2007
Abstract
Several marine bacterial strains, which were isolated from seawater off the island Dokdo, Korea, were screened to find new bioactive compounds such as antibiotics. Among them, Donghaeana dokdonensis strain DSW-6 was found to produce antibacterial agents, and the agents were then purified and analyzed by LC-MS/MS and 1D- and 2D-NMR spectrometries. The bioactive compounds were successfully identified as cholic acid and glycine-conjugated glycocholic acid, the 7α-dehydroxylated derivatives (deoxycholic acid and glycodeoxycholic acid) of which were also detected in relatively small amounts. Other marine isolates, taxonomically different from DSW-6, were also able to produce the compounds in a quite different production ratio from DSW-6. As far as we are aware of, these bile acids are produced by specific members of the genus Streptomyces and Myroides, and thought to be general secondary metabolites produced by a variety of bacterial taxa that are widely distributed in the sea.
Keyword
7α-dehydroxylationbile acidcholic acidglycocholic acid
ISSN
1017-7825
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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