(Aryloxyacetylamino)benzoic acid analogues: a new class of hypoxia-inducible factor-1 inhibitors

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Title
(Aryloxyacetylamino)benzoic acid analogues: a new class of hypoxia-inducible factor-1 inhibitors
Author(s)
Kyeong Lee; J H Lee; S K Boovanahalli; Y Jin; M Lee; X Jin; Jin Hwan Kim; Young-Soo Hong; Jung Joon Lee
Bibliographic Citation
Journal of Medicinal Chemistry, vol. 50, no. 7, pp. 1675-1684
Publication Year
2007
Abstract
Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.
ISSN
0022-2623
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/jm0610292
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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