Upregulation of galectin-3 by Corynebacterium kutscheri infection in the rat lung

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Title
Upregulation of galectin-3 by Corynebacterium kutscheri infection in the rat lung
Author(s)
Young Suk Won; E S Jeong; Hyun Ji Park; Chul Ho LeeKi Hoan NamHyoung-Chin Kim; J I Park; Y K Choi
Bibliographic Citation
Experimental Animals, vol. 56, no. 2, pp. 85-91
Publication Year
2007
Abstract
Corynebacterium (C) kutscheri and Staphylococcus aureus were isolated from two Sprague-Dawley (SD) rats with a hemisected spinal cord. Grossly, gray-white bulging foci and abscesses were distributed throughout the parenchyma of the lung. Pathologically, severe necrotizing lobar pneumonia with abscesses and fibrinous pleuritis were observed. Immunohistochemical analysis found accumulation of galectin-3 in alveolar macrophages and the alveolar interstitial region. No other viral or bacterial pathogens were detected in these animals. In addition, similar pathogenic changes and accumulation of galectin-3 were observed in the lungs of SD rats experimentally infected with C. kutscheri. Using northern blot analysis, the relative galectin-3 and GAPDH mRNA levels were 4.6 to 9.3 times higher in C. kutscheri-infected lung than in uninfected controls. These results demonstrate that a single C. kutscheri infection can induce the upregulation of galectin-3 in the lung and that this molecule may have an important pathogenic role in C. kutscheri infections in rats.
Keyword
corynebacterium kutscherigalectin-3immunohistochemicalstaphylococcus aureus
ISSN
1341-1357
Publisher
Int Press Editing Centre Inc
DOI
http://dx.doi.org/10.1538/expanim.56.85
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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