Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2

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Title
Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2
Author(s)
Su-Kyung Lee; Hyo Kon Chun; J Y Yang; Dong Cho HanKwang Hee Son; Byoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry, vol. 15, no. 12, pp. 4085-4090
Publication Year
2007
Abstract
Because the activation of matrix metalloproteinases (MMP) is a key factor in the metastatic process, compounds with the ability to inhibit MMP activity have a potential in the treatment of tumor. From the examination of 2000 plant extracts, obovatal isolated from the extract of the leaves of Magnolia obovata THUNB was a potent inhibitor of MMP-2 enzyme in vitro. In human fibrosarcoma cells (HT1080) activated with MMP-2, obovatal inhibited MMP-2 enzyme activity and expression. In addition, the compound blocked migration and invasion of the cells. This study demonstrates that obovatal exerts its anticancer effects through blocking migration and invasion by inhibition of MMP-2 expression and activity, and also will be a good lead molecule for the development of anti-tumor drug.
Keyword
Cell invasionCell migrationMagnolia obovata THUNBMatrix metalloproteinase-2 (MMP-2)Obovatal
ISSN
0968-0896
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmc.2007.03.081
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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