Diarylheptanoids from Alnus hirsuta inhibit the NF-κB activation and NO and TNF-α production

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Title
Diarylheptanoids from Alnus hirsuta inhibit the NF-κB activation and NO and TNF-α production
Author(s)
W Y Jin; X F Cai; Min Kyun Na; Jung Joon Lee; K H Bae
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 30, no. 4, pp. 810-813
Publication Year
2007
Abstract
Six diarylheptanoids (1-6) from the stem bark of Alnus hirsuta were investigated for their inhibitory activity against LPS-induced NF-kB activation and NO and TNF-alpha production. Among them, compounds 2, 3, and 6 displayed inhibitory activity against NF-kB activation and NO and TNF-alpha production with IC50 values of 9.2-9.9 microM, 18.2-19.3 microM, and 22.3-23.7 microM, respectively, in RAW264.7 cells. Three active compounds had no significant cytotoxicity in RAW264.7 cells at their effective concentrations. This is the first report of NF-kB-inhibitory activity of these compounds and supports the pharmacological use of A. hirsuta, which has been employed as a herbal medicine for the treatment of inflammatory diseases.
Keyword
Alnus hirsutaDiarylheptanoidNF-kB activationNO productionTNF-α production
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.30.810
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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