Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus

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dc.contributor.authorJ G Lee-
dc.contributor.authorIck Dong Yoo-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2017-04-19T09:07:02Z-
dc.date.available2017-04-19T09:07:02Z-
dc.date.issued2007-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.30.795ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7890-
dc.description.abstractBenzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC 50 values of 1.92, 0.53, and 1.99 μg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.-
dc.publisherPharmaceutical Soc Japan-
dc.titleDifferential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus-
dc.title.alternativeDifferential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number4-
dc.citation.endPage797-
dc.citation.startPage795-
dc.citation.volume30-
dc.contributor.affiliatedAuthorIck Dong Yoo-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeName이종교-
dc.contributor.alternativeName유익동-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 30, no. 4, pp. 795-797-
dc.identifier.doi10.1248/bpb.30.795-
dc.subject.keywordAntiviral activity-
dc.subject.keywordBenzastatin C-
dc.subject.keywordChloro-tetrahydroquinolone-
dc.subject.keywordStreptomyces nitrosporeus-
dc.subject.localAntiviral activity-
dc.subject.localantiviral activity-
dc.subject.localBenzastatin C-
dc.subject.localChloro-tetrahydroquinolone-
dc.subject.localStreptomyces nitrosporeus-
dc.subject.localstreptomyces nitrosporeus-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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