Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application

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Title
Cleavage-induced fluorescence change via hydrophilicity control: A new strategy for biological application
Author(s)
C K Lim; J S Lee; Tai-Hwan Ha; I C Kwon; C H Ahn; S Y Park
Bibliographic Citation
Journal of Photochemistry and Photobiology A-Chemistry, vol. 188, no. 2, pp. 149-154
Publication Year
2007
Abstract
In this work, we report a novel stimuli-sensitive probe working on the principle of the cleavage-induced fluorescent change via hydrophilicity control. In our Si-Py-Ac-PEG probe, cleavage of hydrophilic PEG moiety in acidic environment induces hydrophobic interaction of pyrenes to increase their excimer emission. Our fluorescent probe (Si-Py-Ac-PEG) was successfully applied to the spotting microarray and nanoparticle suspension to demonstrate the potential of biological applications, i.e. protein chip and bioimaging.
Keyword
biomedical imagingcleavageexcimer emissionhydrophilicity controlmicroarray
ISSN
1010-6030
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jphotochem.2006.12.002
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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