Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum thunb.

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dc.contributor.authorS G Choi-
dc.contributor.authorJ Kim-
dc.contributor.authorN D Sung-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorH G Cheon-
dc.contributor.authorK R Kim-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T09:07:04Z-
dc.date.available2017-04-19T09:07:04Z-
dc.date.issued2007-
dc.identifier.issn1029-2349-
dc.identifier.uri10.1080/14786410601012265ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7902-
dc.description.abstractThree anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC50 values of 62.5, 30, and 34 μg mL-1, respectively. Emodin (2) and questin (3) strongly inhibited the growth of human colon cancer cells, SW620 with GI50 values of 6.1 and 0.9 μg mL-1, respectively. Commercially available anthraquinones, chrysophanol (4), and rhein (5) also inhibited Cdc25B phosphatase with IC50 values of 10.7 and 22.1 μg mL-1, respectively.-
dc.publisherT&F (Taylor & Francis)-
dc.titleAnthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum thunb.-
dc.title.alternativeAnthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum thunb.-
dc.typeArticle-
dc.citation.titleNatural Product Research-
dc.citation.number6-
dc.citation.endPage493-
dc.citation.startPage487-
dc.citation.volume21-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName최성규-
dc.contributor.alternativeName김지인-
dc.contributor.alternativeName성낙도-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName천혜경-
dc.contributor.alternativeName김광록-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationNatural Product Research, vol. 21, no. 6, pp. 487-493-
dc.identifier.doi10.1080/14786410601012265-
dc.subject.keywordAnthraquinones-
dc.subject.keywordCdc25B phosphatase-
dc.subject.keywordPolygonum multiflorum-
dc.subject.localAnthraquinone-
dc.subject.localAnthraquinones-
dc.subject.localCdc25B phosphatase-
dc.subject.localpolygonum multiflorum-
dc.subject.localPolygonum multiflorum-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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