Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells

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dc.contributor.authorS S Hong-
dc.contributor.authorS A Lee-
dc.contributor.authorX H Han-
dc.contributor.authorH Z Jin-
dc.contributor.authorJ H Lee-
dc.contributor.authorD Lee-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorJ T Hong-
dc.contributor.authorY Kim-
dc.contributor.authorJ S Ro-
dc.contributor.authorB Y Hwang-
dc.date.accessioned2017-04-19T09:07:14Z-
dc.date.available2017-04-19T09:07:14Z-
dc.date.issued2007-
dc.identifier.issn0163-3864-
dc.identifier.uri10.1021/np060638+ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7918-
dc.description.abstractAs part of an ongoing search for plant-derived compounds that inhibit the activation of NF-κB, the methanol extract of the aerial parts of Isodon excisus was found to have significant inhibitory effects on the activation of NF-κB in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded five new diterpenoids, excisusin A-E (1-5), along with seven known compounds, inflexarabdonin I (6), inflexarabdonin G (7), inflexin (8), inflexanin A (9), inflexanin B (10), inflexinol (11), and inflexarabdonin A (12). The structures were determined by analysis of the spectroscopic data including 2D NMR. All of the isolates were evaluated for their inhibitory effects on LPS-induced NF-κB activation and nitric oxide production in RAW264.7 cells.-
dc.publisherAmer Chem Soc-
dc.titleKaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells-
dc.title.alternativeKaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number4-
dc.citation.endPage636-
dc.citation.startPage632-
dc.citation.volume70-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeName홍성수-
dc.contributor.alternativeName이선아-
dc.contributor.alternativeNameHan-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName이정형-
dc.contributor.alternativeName이동호-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName홍진태-
dc.contributor.alternativeName김영수-
dc.contributor.alternativeName노재섭-
dc.contributor.alternativeName황방연-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 70, no. 4, pp. 632-636-
dc.identifier.doi10.1021/np060638+-
dc.description.journalClassY-
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