Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-κB pathway in Raw 264.7 murine macrophages

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dc.contributor.authorEun Yi Moon-
dc.contributor.authorS Pyo-
dc.date.accessioned2017-04-19T09:07:15Z-
dc.date.available2017-04-19T09:07:15Z-
dc.date.issued2007-
dc.identifier.issn0165-2478-
dc.identifier.uri10.1016/j.imlet.2007.04.002ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7926-
dc.description.abstractNuclear factor-kappa B (NF-κB) is regulated by various stimulants to show many physiological results. Lipopolysaccharide (LPS) activates NF-κB through toll-like receptor 4 (TLR4)-dependent signal transduction. LPS-treatment also produces cyclic AMP (cAMP) in Raw 264.7 murine macrophages. Two principal effector proteins for cAMP are protein kinase A (PKA) and cAMP-responsive guanine nucleotide exchange factor (Epac), a Rap GDP exchange factor. Here, we investigated whether NF-κB can be activated by cAMP production through Epac1-mediated Rap1 activation by using Epac-specific cAMP analogue, 8-(4-chloro-phenylthio)-2′-O-methyladenosine-3′,5′-cyclic monophosphate (CPT). NF-κB activity was increased by the treatment with CPT but it was reduced by co-transfection with dominant negative of Rap1 (Rap1N17). In conclusion, NF-κB activation should be regulated through Epac1-mediated Rap1 stimulation for LPS-induced inflammatory responses in murine macrophages. It suggests that Epac1-mediated Rap1/NF-κB pathway could be helpful for interpretation on various cAMP-mediated physiological responses and it could be used as a target to control their pathological abnormalities.-
dc.publisherElsevier-
dc.titleLipopolysaccharide stimulates Epac1-mediated Rap1/NF-κB pathway in Raw 264.7 murine macrophages-
dc.title.alternativeLipopolysaccharide stimulates Epac1-mediated Rap1/NF-κB pathway in Raw 264.7 murine macrophages-
dc.typeArticle-
dc.citation.titleImmunology Letters-
dc.citation.number2-
dc.citation.endPage125-
dc.citation.startPage121-
dc.citation.volume110-
dc.contributor.affiliatedAuthorEun Yi Moon-
dc.contributor.alternativeName문은이-
dc.contributor.alternativeName표석녕-
dc.identifier.bibliographicCitationImmunology Letters, vol. 110, no. 2, pp. 121-125-
dc.identifier.doi10.1016/j.imlet.2007.04.002-
dc.subject.keywordcAMP-
dc.subject.keywordEpac1-
dc.subject.keywordLPS-
dc.subject.keywordNF-κB-
dc.subject.keywordPKA-
dc.subject.keywordRap1-
dc.subject.localcAMP-
dc.subject.localCAMP-
dc.subject.localEpac1-
dc.subject.localLPS-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localPKA-
dc.subject.localRAP1-
dc.subject.localRap1-
dc.description.journalClassY-
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