Environmental effects on gene expression phenotype have regional biases in the human genome

Cited 45 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJung Kyoon Choi-
dc.contributor.authorS C Kim-
dc.date.accessioned2017-04-19T09:07:16Z-
dc.date.available2017-04-19T09:07:16Z-
dc.date.issued2007-
dc.identifier.issn0016-6731-
dc.identifier.uri10.1534/genetics.106.069047ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7930-
dc.description.abstractPhenotypic discordance between monozygotic twins, such as a difference in disease susceptibility, implicates the role of the environment in determining phenotype. To assess genomewide environmental effects on "gene expression phenotype," we employed a published microarray data set for twins. We found that variations in expression phenotypes between monozygotic twins have biases in their chromosomal locations. They also showed a strong inverse correlation with gene density. Genomic regions of low gene density were environmentally sensitive, containing genes involved in response to external signals, cell differentiation, and development, etc. Genetic factors were found to make no contribution to the observed regional biases, stressing the role of epigenetics. We propose that epigenetic modifications might occur more frequently in heterochromatic, gene-poor regions in response to environmental signals while gene-rich regions tend to remain in an active chromatin configuration for the constitutive expression of underlying genes.-
dc.publisherGenetics Society America-
dc.titleEnvironmental effects on gene expression phenotype have regional biases in the human genome-
dc.title.alternativeEnvironmental effects on gene expression phenotype have regional biases in the human genome-
dc.typeArticle-
dc.citation.titleGenetics-
dc.citation.number4-
dc.citation.endPage1613-
dc.citation.startPage1607-
dc.citation.volume175-
dc.contributor.affiliatedAuthorJung Kyoon Choi-
dc.contributor.alternativeName최정균-
dc.contributor.alternativeName김상철-
dc.identifier.bibliographicCitationGenetics, vol. 175, no. 4, pp. 1607-1613-
dc.identifier.doi10.1534/genetics.106.069047-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.