Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone

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Title
Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone
Author(s)
Hyeong Kyu Lee; Sei Ryang OhOk Kyoung KwonKyung Seop Ahn; Joongku Lee; J C Kim; B S Min; Hyouk Joung
Bibliographic Citation
Phytotherapy Research, vol. 21, no. 5, pp. 406-409
Publication Year
2007
Abstract
A new coumarin, hydroxylomatin (1), was isolated from the CHCl 3,-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including khellactone (3). The structure of hydroxylomatin (1) was determined to be 3′5′-dihydroxy-3′,4′-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia. This study also examined the antitumor activity of khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a TIC (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice.
Keyword
Angelica purpuraefoliaAntitumor activityHydroxylomatinKhellactoneUmbelliferae
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.2082
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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