Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

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Title
Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages
Author(s)
Z Q Chang; B C Oh; M H Rhee; J C Kim; S P Lee; S C Park
Bibliographic Citation
World Journal of Microbiology & Biotechnology, vol. 23, no. 5, pp. 723-727
Publication Year
2007
Abstract
Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 μg ml-1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml -1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.
Keyword
Nitric oxidePhellinus baumiiPolysaccharideSplenocyte proliferation
ISSN
0959-3993
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s11274-006-9277-3
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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