Triterpenoids and diarylheptanoids from alnus hirsuta inhibit HIF-1 in AGS cells

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dc.contributor.authorW Y Jin-
dc.contributor.authorX F Cai-
dc.contributor.authorM K Na-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorK H Bae-
dc.date.accessioned2017-04-19T09:07:18Z-
dc.date.available2017-04-19T09:07:18Z-
dc.date.issued2007-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/BF02980213ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7943-
dc.description.abstractBioassay-guided fractionation and purification of the EtOAc soluble fraction from the MeOH extract of the stem bark of Alnus hirsuta (Betulaceae), using an in vitro HIF-1 assay, led to the isolation of four triterpenoids (1-4) and six diarylheptanoids (5-10). Their structures were determined by comparison with the physicochemical and spectroscopic data in the literature. These compounds were investigated for their effects on the hypoxia-induced HIF-1 activation using an HIF-1a mediated reporter gene assay in AGS cells. Among them, two diarylheptanoids, 2-oxatrycyclo[13.2.2.13,7]eicosa-3,5,7(20),15,17,18- hexaen-10-16-diol (6) and 2-oxatrycyclo [13.2.2.13,7]eicosa-3,5,7-(20),15,17,18- hexaen-10-one (7), inhibited HIF-1 activation dose-dependently with IC 50 values of 11.2 μM and 12.3 μ M, respectively. These two compounds had no significant cytotoxicity to the AGS cells at the effective concentration for the inhibition of HIF-1 activation.-
dc.publisherPharmaceutical Soc Korea-
dc.titleTriterpenoids and diarylheptanoids from alnus hirsuta inhibit HIF-1 in AGS cells-
dc.title.alternativeTriterpenoids and diarylheptanoids from alnus hirsuta inhibit HIF-1 in AGS cells-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number4-
dc.citation.endPage418-
dc.citation.startPage412-
dc.citation.volume30-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeNameCai-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName배기환-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 30, no. 4, pp. 412-418-
dc.identifier.doi10.1007/BF02980213-
dc.subject.keywordalnus hirsuta-
dc.subject.keywordbetulaceae-
dc.subject.keyworddiarylheptanoid-
dc.subject.keywordHIF-1 activation-
dc.subject.keywordtriterpenoid-
dc.subject.localalnus hirsuta-
dc.subject.localAlnus hirsuta-
dc.subject.localbetulaceae-
dc.subject.localBetulaceae-
dc.subject.localdiarylheptanoids-
dc.subject.localDiarylheptanoids-
dc.subject.localDiarylheptanoid-
dc.subject.localdiarylheptanoid-
dc.subject.localHIF-1 activation-
dc.subject.localtriterpenoid-
dc.subject.localTriterpenoid-
dc.subject.localTriterpenoids-
dc.subject.localtriterpenoids-
dc.description.journalClassY-
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