DC Field | Value | Language |
---|---|---|
dc.contributor.author | X H Han | - |
dc.contributor.author | S S Hong | - |
dc.contributor.author | D Lee | - |
dc.contributor.author | Jung Joon Lee | - |
dc.contributor.author | M S Lee | - |
dc.contributor.author | D C Moon | - |
dc.contributor.author | K Han | - |
dc.contributor.author | K W Oh | - |
dc.contributor.author | M K Lee | - |
dc.contributor.author | J S Ro | - |
dc.contributor.author | B Y Hwang | - |
dc.date.accessioned | 2017-04-19T09:07:18Z | - |
dc.date.available | 2017-04-19T09:07:18Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | 10.1007/BF02980210 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7944 | - |
dc.description.abstract | 1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]-4(1H)- quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)- quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots. | - |
dc.publisher | Pharmaceutical Soc Korea | - |
dc.title | Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase | - |
dc.title.alternative | Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase | - |
dc.type | Article | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 401 | - |
dc.citation.startPage | 397 | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Jung Joon Lee | - |
dc.contributor.alternativeName | Han | - |
dc.contributor.alternativeName | 홍성수 | - |
dc.contributor.alternativeName | 이동호 | - |
dc.contributor.alternativeName | 이정준 | - |
dc.contributor.alternativeName | 이문순 | - |
dc.contributor.alternativeName | 문동철 | - |
dc.contributor.alternativeName | 한군 | - |
dc.contributor.alternativeName | 오기완 | - |
dc.contributor.alternativeName | 이명구 | - |
dc.contributor.alternativeName | 노재섭 | - |
dc.contributor.alternativeName | 황방연 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 30, no. 4, pp. 397-401 | - |
dc.identifier.doi | 10.1007/BF02980210 | - |
dc.subject.keyword | evodia rutaecarpa | - |
dc.subject.keyword | evodiae fructus | - |
dc.subject.keyword | monoamine oxidase inhibitor | - |
dc.subject.keyword | quinolone alkaloid | - |
dc.subject.keyword | rutaceae | - |
dc.subject.local | evodia rutaecarpa | - |
dc.subject.local | Evodia rutaecarpa | - |
dc.subject.local | Evodiae fructus | - |
dc.subject.local | evodiae fructus | - |
dc.subject.local | monoamine oxidase inhibitor | - |
dc.subject.local | Quinolone alkaloid | - |
dc.subject.local | quinolone alkaloid | - |
dc.subject.local | rutaceae | - |
dc.subject.local | Rutaceae | - |
dc.description.journalClass | Y | - |
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