Gradual development of a genome-wide H3-K9 trimethylation pattern in paternally derived pig pronucleus = 히스톤 H3-K9 trimethylation pattern의 pig zygote에서의 확립 과정 연구

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dc.contributor.authorYoung Sun Jeong-
dc.contributor.authorSeungeun Yeo-
dc.contributor.authorJung Sun Park-
dc.contributor.authorKyung Kwang Lee-
dc.contributor.authorYong-Kook Kang-
dc.date.accessioned2017-04-19T09:07:19Z-
dc.date.available2017-04-19T09:07:19Z-
dc.date.issued2007-
dc.identifier.issn1058-8388-
dc.identifier.uri10.1002/dvdy.21150ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7947-
dc.description.abstractThe cytoplasm of a mature oocyte contains many protein complexes that are programmed to restructure incoming sperm chromatins on fertilization. of the complicated biochemical events that these functional machineries control, the most impressive and important is epigenetic reprogramming. Despite its importance in epigenetic resetting, or "de-differentiation," of gamete genomes back to an incipient status, the mechanisms of epigenetic reprogramming do not seem to be conserved among mammals. Here, we report that, unlike in the mouse, the pig sperm-derived pronucleus is markedly trimethylated at lysine 9 of histone H3 (H3-m3K9), which might be associated with preservation of paternally derived cytosine methylation in pig zygotes. The male H3-m 3K9 pattern is gradually established during pronucleus development, and this process occurs independently of DNA replication. Considering these unique epigenetic features, the pig zygote is, we believe, suited to serve as another model of epigenetic reprogramming that is antithetical to the well-characterized mouse model.-
dc.publisherWiley-
dc.titleGradual development of a genome-wide H3-K9 trimethylation pattern in paternally derived pig pronucleus = 히스톤 H3-K9 trimethylation pattern의 pig zygote에서의 확립 과정 연구-
dc.title.alternativeGradual development of a genome-wide H3-K9 trimethylation pattern in paternally derived pig pronucleus-
dc.typeArticle-
dc.citation.titleDevelopmental Dynamics-
dc.citation.number6-
dc.citation.endPage1516-
dc.citation.startPage1509-
dc.citation.volume236-
dc.contributor.affiliatedAuthorYoung Sun Jeong-
dc.contributor.affiliatedAuthorSeungeun Yeo-
dc.contributor.affiliatedAuthorJung Sun Park-
dc.contributor.affiliatedAuthorKyung Kwang Lee-
dc.contributor.affiliatedAuthorYong-Kook Kang-
dc.contributor.alternativeName정영선-
dc.contributor.alternativeName여승은-
dc.contributor.alternativeName박정선-
dc.contributor.alternativeName이경광-
dc.contributor.alternativeName강용국-
dc.identifier.bibliographicCitationDevelopmental Dynamics, vol. 236, no. 6, pp. 1509-1516-
dc.identifier.doi10.1002/dvdy.21150-
dc.subject.keywordActive demethylation-
dc.subject.keywordEarly embryo-
dc.subject.keywordEpigenetic reprogramming-
dc.subject.keywordH3-K9 methylation-
dc.subject.keywordPig-
dc.subject.localactive demethylation-
dc.subject.localActive demethylation-
dc.subject.localEarly embryo-
dc.subject.localEarly Embryo-
dc.subject.localearly embryo-
dc.subject.localEpigenetic reprogramming-
dc.subject.localepigenetic reprogramming-
dc.subject.localH3-K9 methylation-
dc.subject.localPigs-
dc.subject.localpigs-
dc.subject.localPig-
dc.subject.localpig-
dc.description.journalClassY-
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
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