Fumimycin: a peptide deformylase inhibitor with an unusual skeleton produced by Aspergillus fumisynnematus

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Title
Fumimycin: a peptide deformylase inhibitor with an unusual skeleton produced by Aspergillus fumisynnematus
Author(s)
Y J Kwon; Mi Jin Sohn; Chang-Ji Zheng; Won Gon Kim
Bibliographic Citation
Organic Letters, vol. 9, no. 13, pp. 2449-2451
Publication Year
2007
Abstract
Fumimycin, an unusual metabolite incorporating an unuaual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to Inhibit Staphylococcus aureus peptide deformylase with an IC50 value of 4.1 μM and also showed antibacterial activity against S. aureus.
ISSN
1523-7060
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/ol0703231
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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