Open Access@KRIBBDivision of Research on National ChallengesInfectious Disease Research Center1. Journal Articles
Fumimycin: a peptide deformylase inhibitor with an unusual skeleton produced by Aspergillus fumisynnematus
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- Title
- Fumimycin: a peptide deformylase inhibitor with an unusual skeleton produced by Aspergillus fumisynnematus
- Author(s)
- Y J Kwon; Mi Jin Sohn; Chang-Ji Zheng; Won Gon Kim
- Bibliographic Citation
- Organic Letters, vol. 9, no. 13, pp. 2449-2451
- Publication Year
- 2007
- Abstract
- Fumimycin, an unusual metabolite incorporating an unuaual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to Inhibit Staphylococcus aureus peptide deformylase with an IC50 value of 4.1 μM and also showed antibacterial activity against S. aureus.
- ISSN
- 1523-7060
- Publisher
- Amer Chem Soc
- Full Text Link
- http://dx.doi.org/10.1021/ol0703231
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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