Cytotoxic constituents from Angelicae Sinensis Radix

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dc.contributor.authorQ C Chen-
dc.contributor.authorJ P Lee-
dc.contributor.authorWenYi Jin-
dc.contributor.authorU J Youn-
dc.contributor.authorH J Kim-
dc.contributor.authorI S Lee-
dc.contributor.authorX F Zhang-
dc.contributor.authorK S Song-
dc.contributor.authorY H Seong-
dc.contributor.authorK H Bae-
dc.date.accessioned2017-04-19T09:07:27Z-
dc.date.available2017-04-19T09:07:27Z-
dc.date.issued2007-
dc.identifier.issn0253-6269-
dc.identifier.uri10.1007/BF02977650ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7955-
dc.description.abstractCytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimeric Z-ligustilide, named neodiligustilide (1), together with three known compounds, Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z,17-dien-12,14-diyn-1-yl acetate (3), and 3(R),8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 ± 0.10 and 4.78 ± 0.18 μM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 ± 0.19 and 9.87 ± 0.14 μM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 ± 0.90 and 2.87 ± 0.49 μM, respectively.-
dc.publisherPharmaceutical Soc Korea-
dc.titleCytotoxic constituents from Angelicae Sinensis Radix-
dc.title.alternativeCytotoxic constituents from Angelicae Sinensis Radix-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number5-
dc.citation.endPage569-
dc.citation.startPage565-
dc.citation.volume30-
dc.contributor.affiliatedAuthorWenYi Jin-
dc.contributor.alternativeNameChen-
dc.contributor.alternativeName이종필-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName윤의정-
dc.contributor.alternativeName김홍진-
dc.contributor.alternativeName이익수-
dc.contributor.alternativeNameZhang-
dc.contributor.alternativeName송경식-
dc.contributor.alternativeName성연희-
dc.contributor.alternativeName배기환-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 30, no. 5, pp. 565-569-
dc.identifier.doi10.1007/BF02977650-
dc.subject.keywordangelicae sinensis radix-
dc.subject.keywordcytotoxicity-
dc.subject.keywordneodiligustilide-
dc.subject.keywordangelica sinensis-
dc.subject.localangelicae sinensis radix-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.subject.localneodiligustilide-
dc.subject.localangelica sinensis-
dc.description.journalClassY-
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